ArticleCancer cell2007
Telomeres limit cancer growth by inducing senescence: long-sought in vivo evidence obtained.
Article in Cancer cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1-Dependent Regulation of MAD2L1 mRNA Stability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.Molecular and cellular biology · 2017Article
- Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Genes & cancer · 2014Article
- Assessing cell and organ senescence biomarkers.Circulation research · 2012Review
- Comparative cellular biogerontology: primer and prospectus.Ageing research reviews · 2011Review
- miR-17-92 cluster: ups and downs in cancer and aging.Biogerontology · 2010Article
- Telomeres and disease.The EMBO journal · 2009Review
- Diphosphoinositol polyphosphates: metabolic messengers?Molecular pharmacology · 2009Review
- Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan.Aging cell · 2008Article
- Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.Gastroenterology · 2008Article
- Transformation, genomic instability and senescence mediated by platelet/megakaryocyte glycoprotein Ibalpha.Oncogene · 2008Article
- Shelterin complex and associated factors at human telomeres.Nucleus (Austin, Tex.)Review
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence triggered by telomere dysfunction has long been hypothesized to constitute a tumor suppression mechanism. The evidence has come primarily from in vitro cell culture studies, and more indirectly from analysis of tumor specimens. Two recent studies, published in the current issue of Cancer Cell and online at EMBO Reports, provide direct mechanistic evidence in cleverly manipulated mouse cancer models. This work shows that telomere-induced senescence is as effective as apoptosis in reducing cancer incidence and is mediated by the tumor suppressor p53.
Indexed as
Identifiers
17482128What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.