Evidence map›Paper›PMID 17481836›Full record

Trial reportForensic science international2008

Excretion of Delta9-tetrahydrocannabinol in sweat.

Marilyn A Huestis, Karl B Scheidweiler, Takeshi Saito, Neil Fortner, Tsadik Abraham, Richard A Gustafson, Michael L Smith

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Forensic science international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Impact of 2 Weeks of Monitored Abstinence on Cognition in Adolescent and Young Adult Cannabis Users.Journal of the International Neuropsychological Society : JINS · 2020
    Article
  7. Review
  8. [Testing for cannabis and synthetic cannabinoids in human specimens].Bulletin de l'Academie nationale de medecine · 2020
    Review
  9. Article
  10. Article
  11. Recent developments in sweat analysis and its applications.International journal of analytical chemistry · 2015
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Marilyn A HuestisChemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. mhuestis@intra.nida.nih.gov
Karl B Scheidweiler
Takeshi Saito
Neil Fortner
Tsadik Abraham
Richard A Gustafson
Michael L Smith
National Institutes of Health · USArmed Forces Institute of Pathology · USNational Institute on Drug Abuse · USTokai University · JPUnited States Department of the Navy · US

Funding

Detection Of Drugs Of Abuse In Biological Fluids/TissuesZ01DA000412 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HUESTIS, MARILYN · 1998 to 2008
$956k
PHARMACOKINETICS AND PHARMACODYNAMICS OF DRUGS OF ABUSEZ01DA000414 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HUESTIS, MARILYN A · 1998 to 2008
$373k
Intramural NIH HHS Z01 DA000412Intramural NIH HHS Z01 DA000414
6 · The paper itself

Abstract

Sweat testing is a noninvasive technique for monitoring drug exposure over a 7-day period in treatment, criminal justice, and employment settings. We evaluated Delta(9)-tetrahydrocannabinol (THC) excretion in 11 daily cannabis users after cessation of drug use. PharmChek sweat patches worn for 7 days were analyzed for THC by gas chromatography-mass spectrometry (GC/MS). The limit of quantification (LOQ) for the method was 0.4 ng THC/patch. Sweat patches worn the first week of continuously monitored abstinence had THC above the United States Substance Abuse Mental Health Services Administration's proposed cutoff concentration for federal workplace testing of 1 ng THC/patch. Mean+/-S.E.M. THC concentrations were 3.85+/-0.86 ng THC/patch. Eight of 11 subjects had negative patches the second week and one produced THC positive patches for 4 weeks of monitored abstinence. We also tested daily and weekly sweat patches from seven subjects who were administered oral doses of up to 14.8 mg THC/day for five consecutive days. In this oral THC administration study, no daily or weekly patches had THC above the LOQ; concurrent plasma THC concentrations were all less than 6.1 microg/L. In conclusion, using proposed federal cutoff concentrations, most daily cannabis users will have a positive sweat patch in the first week after ceasing drug use and a negative patch after subsequent weeks, although patches may remain positive for 4 weeks or more. Oral ingestion of up to 14.8 mg THC daily does not produce a THC positive sweat patch test.

Indexed as

Administration, OralAdultDouble-Blind MethodDronabinolFemaleForensic ToxicologyGas Chromatography-Mass SpectrometryHumansMaleMarijuana AbusePsychotropic DrugsSubstance Abuse DetectionSweatTime FactorsDronabinolPsychotropic Drugs

Identifiers

PMID17481836
PMCPMC2277330
OpenAlexW2007727689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.