ReviewPhysiology & behavior2007
Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides.
Review in Physiology & behavior, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function.Frontiers in behavioral neuroscience · 2020Review
- Article
- Lateral Hypothalamus GABAergic Neurons Modulate Consummatory Behaviors Regardless of the Caloric Content or Biological Relevance of the Consumed Stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study.Journal of translational medicine · 2016Article
- TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons.Molecular metabolism · 2015Article
- Serum Proenkephalin A Levels and Mortality After Long-Term Follow-Up in Patients with Type 2 Diabetes Mellitus (ZODIAC-32).PloS one · 2015Observational
- Chronic alcohol consumption from adolescence-to-adulthood in mice--hypothalamic gene expression changes in the dilated cardiomyopathy signaling pathway.BMC neuroscience · 2014Article
- Glutamatergic input to the lateral hypothalamus stimulates ethanol intake: role of orexin and melanin-concentrating hormone.Alcoholism, clinical and experimental research · 2013Article
- Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers.Alcohol (Fayetteville, N.Y.) · 2012Article
- A history of bingeing on fat enhances cocaine seeking and taking.Behavioral neuroscience · 2011Article
- Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Regulation of drug and palatable food overconsumption by similar peptide systems.Current drug abuse reviews · 2011Review
- Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol.Physiology & behavior · 2011Review
- Chronic high-fat diet drives postnatal epigenetic regulation of μ-opioid receptor in the brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes.Endocrinology · 2010Article
- Alcohol consumption and body weight.Health economics · 2010Article
- Heterogeneity of reward mechanisms.Neurochemical research · 2010Review
- Predictors of ethanol consumption in adult Sprague-Dawley rats: relation to hypothalamic peptides that stimulate ethanol intake.Alcohol (Fayetteville, N.Y.) · 2010Article
- Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus.Alcoholism, clinical and experimental research · 2010Article
- Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas.Alcoholism, clinical and experimental research · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The studies described in this report provide interesting animal models for exploring some of the metabolic and neural antecedents to the over-consumption of fat and alcohol. The results provide strong support for the existence of positive feedback loops that involve a close relation between circulating lipids and orexigenic peptides in dorsal regions of the hypothalamus. The peptides involved in these circuits include galanin, enkephalin, dynorphin and orexin. These peptides are expressed in the paraventricular nucleus and perifornical lateral hypothalamus, and they have very different functions from peptides expressed in the arcuate nucleus. Through mechanisms involving circulating lipids that rise on energy-dense diets, these peptides in the dorsal hypothalamus are each increased by the consumption of fat and ethanol; these nutrients, in turn, stimulate further production of these same peptides that promote overeating and excess drinking. These mechanisms involving non-homeostatic, positive feedback circuits may be required under conditions when food supplies are scarce and periods of gorging are essential to survival. However, they have pathological and sometimes life-threatening consequences in modern society, where fat-rich foods and alcoholic drinks are abundantly available and are contributing to the marked rise over the past 25 years in obesity and diabetes in both children and adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.