Evidence map›Paper›PMID 1748109›Full record

Trial reportEuropean journal of applied physiology and occupational physiology1991

Administration of branched-chain amino acids during sustained exercise--effects on performance and on plasma concentration of some amino acids.

E Blomstrand, P Hassmén, B Ekblom, E A Newsholme

Registry-linked trialAbstract readClinical TrialControlled Clinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology and occupational physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02019316 (The Effect of BioSteel Sports Drink Supplementation on Muscular Fatigue, Cognitive Function, and Recovery Following Sprint Interval Exercise), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02019316 phase1unknown statusnot on this mapstarted 2014, after this paper: background citation

The Effect of BioSteel Sports Drink Supplementation on Muscular Fatigue, Cognitive Function, and Recovery Following Sprint Interval Exercise

TypeinterventionalSponsorUniversity of Western Ontario, CanadaRan2014 to 2014Enrolled15ConditionsFatigueArmsBioSteel Sports Drink, Isoenergetic Control
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 257 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Effects of dietary leucine supplementation on exercise performance.European journal of applied physiology · 2006
    Trial
  13. Trial
  14. Effect of n-3 fatty acids on free tryptophan and exercise fatigue.European journal of applied physiology · 2004
    Trial
  15. Trial
  16. Effect of infusing branched-chain amino acid during incremental exercise with reduced muscle glycogen content.European journal of applied physiology and occupational physiology · 1994
    Trial
  17. Trial
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

E BlomstrandPripps Bryggerier, Research Laboratories, Bromma, Sweden.
P Hassmén
B Ekblom
E A Newsholme
Karolinska Institutet · SEStockholm University · SEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have shown that sustained exercise in human subjects causes an increase in the plasma concentration ratio of free tryptophan: other large neutral amino acids [including the branched-chain amino acids (BCAA)]. This should favour the transport of tryptophan into the brain and also the synthesis of 5-hydroxytryptamine, which is thought to contribute to fatigue during prolonged exercise. A mixture of the three BCAA was given to subjects during a 30-km cross-country race or a marathon (42.2 km) and the effects on mental and physical performances were measured. The mental performance, measured as the performance in the Stroop Colour and Word Test (CWT), was improved after, as compared to before the 30-km cross-country race when a BCAA supplement was given during the race, whereas the CWT scores were similar before and after in the placebo group. The running performance in the marathon was improved for the "slower" runners (3.05 h-3.30 h) when BCAA was taken during the race; however, there was no significant effect on the performance in the "faster" runners (less than 3.05 h). The results showed that both mental and physical performance was improved by an intake of BCAA during exercise. In addition, the effects of exercise on the plasma concentration of the aromatic amino acids were altered when a BCAA supplement was given during the marathon.

Indexed as

AdultAmino AcidsAmino Acids, Branched-ChainBlood GlucoseExerciseFatty Acids, NonesterifiedHumansMalePsychomotor PerformanceRunningAmino AcidsAmino Acids, Branched-ChainBlood GlucoseFatty Acids, Nonesterified

Identifiers

PMID1748109
OpenAlexW2015524100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.