ArticlePLoS genetics2007
Regional variation in the density of essential genes in mice.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Article
- Gene Repositioning Is Under Constraints After Evolutionary Conserved Gene Neighborhood Separate.Frontiers in genetics · 2019Article
- Identifying mouse developmental essential genes using machine learning.Disease models & mechanisms · 2018Article
- Intrachromosomal colocalization strengthens co-expression, co-modification and evolutionary conservation of neighboring genes.BMC genomics · 2018Article
- Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.Nature communications · 2018Article
- The functional diversity of essential genes required for mammalian cardiac development.Genesis (New York, N.Y. : 2000) · 2014Review
- Heritability and genomics of gene expression in peripheral blood.Nature genetics · 2014Article
- Expression-based segmentation of the Drosophila genome.BMC genomics · 2013Article
- ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development.BMC genetics · 2012Article
- Support for multiple classes of local expression clusters in Drosophila melanogaster, but no evidence for gene order conservation.Genome biology · 2011Article
- Genome-wide identification of mouse congenital heart disease loci.Human molecular genetics · 2010Article
- Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?Biochimica et biophysica acta · 2010Review
- Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.PLoS genetics · 2009Article
- Correlation of microsynteny conservation and disease gene distribution in mammalian genomes.BMC genomics · 2009Article
- The szilard hypothesis on the nature of aging revisited.Genetics · 2009Article
- A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.BMC genetics · 2009Article
- Review
- The determinants of gene order conservation in yeasts.Genome biology · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In most species, and particularly in vertebrates, the percentage of genes absolutely required for survival, the essential genes, has not been estimated. To obtain this estimation, we used the mouse as an experimental model to carry out high-efficiency N-ethyl-N-nitrosourea (ENU) mutagenesis screens in two balancer chromosome regions, and compared our results to a third previously published screen. The number of essential genes in each region was predicted based on allele frequencies. We determined that the density of essential genes differs by up to an order of magnitude among genomic regions. This indicates that extrapolating from regional estimates to genome-wide estimates of essential genes has a huge variance. A particularly high density of essential genes on mouse Chromosome 11 coincides with a high degree of regional linkage conservation, providing a possible causal explanation for the density variation. This is the first demonstration of regional variation in essential gene density in the mouse genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.