Trial reportInternational journal of biological sciences2007
Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage.
Trial report in International journal of biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials.Inflammopharmacology · 2021Pooled it
- Coenzyme Q10 for heart failure.The Cochrane database of systematic reviews · 2021Pooled it
- The effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.Lipids in health and disease · 2018Pooled it
- Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials.BMC cardiovascular disorders · 2017Pooled it
- Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.The Cochrane database of systematic reviews · 2016Pooled it
- Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2014Pooled it
- Effects of oral administration of common antioxidant supplements on the energy metabolism of red blood cells. Attenuation of oxidative stress-induced changes in Rett syndrome erythrocytes by CoQ10.Molecular and cellular biochemistry · 2020Trial
- n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease.Nutrients · 2016Trial
- Impact of oral ubiquinol on blood oxidative stress and exercise performance.Oxidative medicine and cellular longevity · 2012Trial
- Statin-Induced Coenzyme Q Deficiency Induces Metabolic Reprogramming in Astrocytes.Antioxidants (Basel, Switzerland) · 2026Article
- Behavioral, physiological, encephalopathological alterations and endoplasmic reticulum stress/apoptotic-related gene transcription in reaction to heat stress in Oreochromis niloticus fish: impact of dietary supplements with Spirulina-Coenzyme Q10 nanoemulsion.Veterinary research communications · 2026Article
- Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2025Article
- The Scavenging Activity of Coenzyme QInternational journal of molecular sciences · 2024Article
- Protective effect of coenzyme Q10 against doxorubicin-induced cardiotoxicity: Scoping review article.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage.Antioxidants (Basel, Switzerland) · 2023Article
- Effects of coenzyme Q10 supplementation on oxidative stress biomarkers following reperfusion in STEMI patients undergoing primary percutaneous coronary intervention.Journal of cardiovascular and thoracic research · 2023Article
- Bioavailability of Reduced Coenzyme Q10 (Ubiquinol-10) in Burn Patients.Metabolites · 2022Article
- A Double-Pronged Sword: XJB-5-131 Is a Suppressor of Somatic Instability and Toxicity in Huntington's Disease.Journal of Huntington's disease · 2022Review
- The Role of Mitochondrial Dysfunction in Atrial Fibrillation: Translation to Druggable Target and Biomarker Discovery.International journal of molecular sciences · 2021Review
- Coenzyme QBMC pharmacology & toxicology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coenzyme Q10 (CoQ10) concentration in blood cells was analyzed by HPLC and compared to plasma concentration before, during, and after CoQ10 (3 mg/kg/day) supplementation to human probands. Lymphocyte DNA 8-hydroxydeoxy-guanosine (8-OHdG), a marker of oxidative stress, was analyzed by Comet assay. Subjects supplemented with CoQ10 showed a distinct response in plasma concentrations after 14 and 28 days. Plasma levels returned to baseline values 12 weeks after treatment stopped. The plasma concentration increase did not affect erythrocyte levels. However, after CoQ10 supplementation, the platelet level increased; after supplementation stopped, the platelet level showed a delayed decrease. A positive correlation was shown between the plasma CoQ10 level and platelet and white blood cell CoQ10 levels. During CoQ10 supplementation, delayed formation of 8-OHdG in lymphocyte DNA was observed; this effect was long-lasting and could be observed even 12 weeks after supplementation stopped. Intracellular enrichment may support anti-oxidative defense mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.