ArticlePlant physiology2007
RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123 citing papers in PubMed, 311 citations in OpenAlex.
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- Integrative transcriptomic and metabolomic analysis reveals the molecular basis of leaf variegation inFrontiers in plant science · 2026Article
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- Regional Variation in Mulberry Leaf Metabolites: A Combined Metabolomic and Environmental Analysis of Biosynthetic Drivers.Metabolites · 2025Article
- Tomato pollen tube growth requires flavonol glycosylation.Plant physiology · 2025Article
- Integrated Transcriptomic and Metabolomic Profiling of Paclobutrazol-Induced Dwarfism in Tomato Epicotyls.Plants (Basel, Switzerland) · 2025Article
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- Joint analysis of transcriptome and metabolome on the accumulation mechanism of flavonoids in quinoa seedlings under flooding stress.BMC plant biology · 2025Article
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- Biosynthesis and Physiological Significance of Organ-Specific Flavonol Glycosides in Solanaceae.bioRxiv : the preprint server for biology · 2025Article
- CRISPR-Cas9-mediated deletions of FvMYB46 in Fragaria vesca reveal its role in regulation of fruit set and phenylpropanoid biosynthesis.BMC plant biology · 2025Article
- Genome-wide identification, characterization and expression analysis of the chalcone synthase gene family in Chinese cabbage.BMC genomics · 2025Article
- Biological Functions and Health Benefits of Flavonoids in Fruits and Vegetables: A Contemporary Review.Foods (Basel, Switzerland) · 2025Review
- Transcriptome reveals differential expression of flavor and color in closely related strains of tomato (PeerJ · 2025Article
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- Integrated transcriptomic and metabolomic analysis of flavonoid biosynthesis in cigar tobacco leaves under variable nitrogen regimes.Frontiers in plant science · 2025Article
- Metabolomic and Transcriptomic Analysis Reveals Flavonoid-Mediated Regulation of Seed Antioxidant Properties in Peanut Seed Vigor.Antioxidants (Basel, Switzerland) · 2024Article
63 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parthenocarpy, the formation of seedless fruits in the absence of functional fertilization, is a desirable trait for several important crop plants, including tomato (Solanum lycopersicum). Seedless fruits can be of great value for consumers, the processing industry, and breeding companies. In this article, we propose a novel strategy to obtain parthenocarpic tomatoes by down-regulation of the flavonoid biosynthesis pathway using RNA interference (RNAi)-mediated suppression of chalcone synthase (CHS), the first gene in the flavonoid pathway. In CHS RNAi plants, total flavonoid levels, transcript levels of both Chs1 and Chs2, as well as CHS enzyme activity were reduced by up to a few percent of the corresponding wild-type values. Surprisingly, all strong Chs-silenced tomato lines developed parthenocarpic fruits. Although a relation between flavonoids and parthenocarpic fruit development has never been described, it is well known that flavonoids are essential for pollen development and pollen tube growth and, hence, play an essential role in plant reproduction. The observed parthenocarpic fruit development appeared to be pollination dependent, and Chs RNAi fruits displayed impaired pollen tube growth. Our results lead to novel insight in the mechanisms underlying parthenocarpic fruit development. The potential of this technology for applications in plant breeding and biotechnology will be discussed.
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