ArticlePlant physiology2007
Tomato mitogen-activated protein kinases LeMPK1, LeMPK2, and LeMPK3 are activated during the Cf-4/Avr4-induced hypersensitive response and have distinct phosphorylation specificities.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 123 citations in OpenAlex.
- Current Understanding of Cell-Surface Immune Receptors for MAMPs and Plant Parasites in the Solanaceae Family.Molecular plant pathology · 2026Review
- Tomato Roots Exhibit Development-Specific Responses to Bacterial-Derived Peptides.Plant, cell & environment · 2025Article
- Jasmonic acid and salicylic acid transcriptionally regulatePlant diversity · 2025Article
- Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Identification of mitogen-activated protein kinases substrates inPlant signaling & behavior · 2024Article
- Companion basil plants prime the tomato wound response through volatile signaling in a mixed planting system.Plant cell reports · 2024Article
- Physiological and molecular responses of a resistant and susceptible wheat cultivar to the fungal wheat pathogen Zymoseptoria tritici.PloS one · 2024Article
- Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans.Molecular plant pathology · 2021Article
- Host susceptibility factors render ripe tomato fruit vulnerable to fungal disease despite active immune responses.Journal of experimental botany · 2021Article
- Red light imaging for programmed cell death visualization and quantification in plant-pathogen interactions.Molecular plant pathology · 2021Article
- The DUF221 domain-containing (DDP) genes identification and expression analysis in tomato under abiotic and phytohormone stress.GM crops & food · 2021Article
- Deep phosphoproteome analysis of Schistosoma mansoni leads development of a kinomic array that highlights sex-biased differences in adult worm protein phosphorylation.PLoS neglected tropical diseases · 2020Article
- The Function of MAPK Cascades in Response to Various Stresses in Horticultural Plants.Frontiers in plant science · 2020Review
- Overexpression of a Mitogen-Activated Protein KinaseMolecules (Basel, Switzerland) · 2019Article
- The Tomato Mitogen-Activated Protein Kinase SlMPK1 Is as a Negative Regulator of the High-Temperature Stress Response.Plant physiology · 2018Article
- BIFURCATE FLOWER TRUSS: a novel locus controlling inflorescence branching in tomato contains a defective MAP kinase gene.Journal of experimental botany · 2018Article
- MAP kinases associate with high molecular weight multiprotein complexes.Journal of experimental botany · 2018Article
- Identification and Analysis of Mitogen-Activated Protein Kinase (MAPK) Cascades in Fragaria vesca.International journal of molecular sciences · 2017Article
- The Ectopic Overexpression of the CottonFrontiers in plant science · 2017Article
- Mitogen-activated protein kinase 4-like carrying an MEY motif instead of a TXY motif is involved in ozone tolerance and regulation of stomatal closure in tobacco.Journal of experimental botany · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato (Solanum lycopersicum) plants with the Cf-4 resistance gene recognize strains of the pathogenic fungus Cladosporium fulvum that secrete the avirulence protein Avr4. Transgenic tomato seedlings coexpressing Cf-4 and Avr4 mount a hypersensitive response (HR) at 20 degrees C, which is suppressed at 33 degrees C. Within 120 min after a shift from 33 degrees C to 20 degrees C, tomato mitogen-activated protein (MAP) kinase (LeMPK) activity increases in Cf-4/Avr4 seedlings. Searching tomato genome databases revealed at least 16 LeMPK sequences, including the sequence of LeMPK1, LeMPK2, and LeMPK3 that cluster with biotic stress-related MAP kinase orthologs from Arabidopsis (Arabidopsis thaliana) and tobacco (Nicotiana tabacum). LeMPK1, LeMPK2, and LeMPK3 are simultaneously activated in Cf-4/Avr4 seedlings, and, to reveal whether they are functionally redundant or not, recombinant LeMPKs were incubated on PepChip Kinomics slides carrying peptides with potential phosphorylation sites. Phosphorylated peptides and motifs present in them discriminated between the phosphorylation specificities of LeMPK1, LeMPK2, and LeMPK3. LeMPK1, LeMPK2, or LeMPK3 activity was specifically suppressed in Cf-4-tomato by virus-induced gene silencing and leaflets were either injected with Avr4 or challenged with C. fulvum-secreting Avr4. The results of these experiments suggested that the LeMPKs have different but also overlapping roles with regard to HR and full resistance in tomato.
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