ArticleThe Journal of physiology2007
Mechano- and chemosensitivity of rat nodose neurones--selective excitatory effects of prostacyclin.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Macrophage activation in stellate ganglia contributes to lung injury-induced arrhythmogenesis in male rats.Acta physiologica (Oxford, England) · 2021Article
- The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH.JCI insight · 2017Article
- TRPC5 channels participate in pressure-sensing in aortic baroreceptors.Nature communications · 2016Article
- Autocrine/paracrine modulation of baroreceptor activity after antidromic stimulation of aortic depressor nerve in vivo.Autonomic neuroscience : basic & clinical · 2014Article
- KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents.American journal of physiology. Cell physiology · 2011Article
- Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC).Advances in genetics · 2011Review
- The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.Neuron · 2009Article
- Reactive oxygen species and inflammatory mediators enhance muscle spindles mechanosensitivity in rats.Pflugers Archiv : European journal of physiology · 2009Article
- Neurobiology of inflammation-associated anorexia.Frontiers in neuroscience · 2009Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Nodose ganglion sensory neurones exert a significant reflex autonomic influence. We contrasted their mechanosensitivity, excitability and chemosensitivity in response to the stable prostacyclin (PGI2) analogue carbacyclin (cPGI) in culture. Under current clamp conditions we measured changes in membrane potential (DeltamV) and action potential (AP) responses to mechanically induced depolarizations and depolarizing current injections before and after superfusion of cPGI (1 microM and 10 microM). Chemosensitivity was indicated by augmentation of AP firing frequency and increased maximum gain of AP frequency (max. dAP/dDeltamV), during superfusion with cPGI. Results indicate that two groups of neurones, A and B, are mechanosensitive (MS) and one group, C, is mechanoinsensitive (MI). Group A shows modest depolarization without AP generation during mechanical stimulation, and no increase in max. dAP/dDeltamV, despite a marked increase in electrical depolarization with cPGI. Group B shows pronounced mechanical depolarization accompanied by enhanced AP discharge with cPGI, and an increase in max. dAP/dDeltamV. Group C remains MI after cPGI but is more excitable and markedly chemosensitive (CS) with a pronounced enhancement of max. dAP/dDeltamV with cPGI. The effect of cPGI on ionic conductances indicates that it does not sensitize the mechanically gated depolarizing degenerin/epithelial Na+ channels (DEG/ENaC), but it inhibits two voltage-gated K+ currents, Maxi-K and M-current, causing enhanced AP firing frequency and depolarization, respectively. We conclude that MS nodose neurones may be unimodal MS or bimodal MS/CS, and that MI neurones are unimodal CS, and much more CS to cPGI than MS/CS neurones. We suggest that the known excitatory effect of PGI2 on baroreceptor and vagal afferent fibres is mediated by inhibition of voltage-gated K+ channels (Maxi-K and M-current) and not by an effect on mechanically gated DEG/ENaC channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.