ArticleNucleic acids research2007
Transcription-coupled deposition of histone modifications during MHC class II gene activation.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Cross-phenotype analysis of Immunochip data identifiesAnnals of the rheumatic diseases · 2018Pooled it
- High-speed multiplexed DNA-PAINT imaging of nuclear organization using an expanded sequence repertoire.Nature communications · 2026Article
- The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.International journal of molecular sciences · 2021Review
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- Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- On the way of revealing coactivator complexes cross-talk during transcriptional activation.Cell & bioscience · 2016Review
- Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes.Epigenetics · 2014Article
- Epigenetic modifications are associated with inter-species gene expression variation in primates.Genome biology · 2014Article
- Promoter analysis reveals globally differential regulation of human long non-coding RNA and protein-coding genes.PloS one · 2014Article
- Interferon-γ resets muscle cell fate by stimulating the sequential recruitment of JARID2 and PRC2 to promoters to repress myogenesis.Science signaling · 2013Article
- CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma.Nucleic acids research · 2012Article
- Article
- Multiple histone methyl and acetyltransferase complex components bind the HLA-DRA gene.PloS one · 2012Article
- Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells.The Journal of biological chemistry · 2011Article
- Regulation of major histocompatibility complex class II genes.Current opinion in immunology · 2011Review
- Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies.Molecular and cellular biology · 2010Article
- Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.Epigenetics & chromatin · 2010Article
- Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site.Nucleic acids research · 2009Article
- Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1.Molecular and cellular biology · 2008Article
- Identification of CIITA regulated genetic module dedicated for antigen presentation.PLoS genetics · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posttranslational histone modifications associated with actively expressed genes are generally believed to be introduced primarily by histone-modifying enzymes that are recruited by transcription factors or their associated co-activators. We have performed a comprehensive spatial and temporal analyses of the histone modifications that are deposited upon activation of the MHC class II gene HLA-DRA by the co-activator CIITA. We find that transcription-associated histone modifications are introduced during two sequential phases. The first phase precedes transcription initiation and is characterized exclusively by a rapid increase in histone H4 acetylation over a large upstream domain. All other modifications examined, including the acetylation and methylation of several residues in histone H3, are restricted to short regions situated at or within the 5' end of the gene and are established during a second phase that is concomitant with ongoing transcription. This second phase is completely abrogated when elongation by RNA polymerase II is blocked. These results provide strong evidence that transcription elongation can play a decisive role in the deposition of histone modification patterns associated with inducible gene activation.
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