ArticleNucleic acids research2007
Lateral flow microarrays: a novel platform for rapid nucleic acid detection based on miniaturized lateral flow chromatography.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 116 citations in OpenAlex.
- A rapid test for protein-DNA interactions.Nucleic acids research · 2026Article
- Microbial Ecotoxicology-40 Years on.Life (Basel, Switzerland) · 2025Article
- Development and validation of a rapid five-minute nucleic acid extraction method for respiratory viruses.Virology journal · 2024Article
- Enhanced Interstitial Fluid Extraction and Rapid Analysis via Vacuum Tube-Integrated Microneedle Array Device.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- Lateral flow assay: a promising rapid point-of-care testing tool for infections and non-communicable diseases.Asian biomedicine : research, reviews and news · 2023Review
- Lateral Flow Microarray-Based ELISA for Cytokines.Methods in molecular biology (Clifton, N.J.) · 2023Article
- REASSURED Multiplex Diagnostics: A Critical Review and Forecast.Biosensors · 2022Review
- Ten Years of Lateral Flow Immunoassay Technique Applications: Trends, Challenges and Future Perspectives.Sensors (Basel, Switzerland) · 2021Review
- Current and emerging trends in point-of-care urinalysis tests.Expert review of molecular diagnostics · 2020Review
- Visual detection of bacterial DNA using activated paper stripe.Mikrochimica acta · 2019Article
- Visual Detection of Dengue-1 RNA Using Gold Nanoparticle-Based Lateral Flow Biosensor.Diagnostics (Basel, Switzerland) · 2019Article
- Nucleic acid lateral flow assays using a conjugate of a DNA binding protein and carbon nanoparticles.Mikrochimica acta · 2019Article
- A fluorometric lateral flow assay for visual detection of nucleic acids using a digital camera readout.Mikrochimica acta · 2018Article
- Fluorescent carbon nanoparticle-based lateral flow biosensor for ultrasensitive detection of DNA.Biosensors & bioelectronics · 2017Article
- Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases.Biotechnology advances · 2016Review
- Aptamer-Phage Reporters for Ultrasensitive Lateral Flow Assays.Analytical chemistry · 2015Article
- Simultaneous detection of nucleic acid and protein using gold nanoparticles and lateral flow device.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2014Article
- Miniaturized technology for protein and nucleic acid point-of-care testing.Translational research : the journal of laboratory and clinical medicine · 2012Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Widely used nucleic acid assays are poorly suited for field deployment where access to laboratory instrumentation is limited or unavailable. The need for field deployable nucleic acid detection demands inexpensive, facile systems without sacrificing information capacity or sensitivity. Here we describe a novel microarray platform capable of rapid, sensitive nucleic acid detection without specialized instrumentation. The approach is based on a miniaturized lateral flow device that makes use of hybridization-mediated target capture. The miniaturization of lateral flow nucleic acid detection provides multiple advantages over traditional lateral flow devices. Ten-microliter sample volumes reduce reagent consumption and yield analyte detection times, excluding sample preparation and amplification, of <120 s while providing sub-femtomole sensitivity. Moreover, the use of microarray technology increases the potential information capacity of lateral flow. Coupled with a hybridization-based detection scheme, the lateral flow microarray (LFM) enables sequence-specific detection, opening the door to highly multiplexed implementations for broad-range assays well suited for point-of-care and other field applications. The LFM system is demonstrated using an isothermal amplification strategy for detection of Bacillus anthracis, the etiologic agent of anthrax. RNA from as few as two B. anthracis cells was detected without thermocycling hardware or fluorescence detection systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.