ArticleBiochimica et biophysica acta2007
Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology.Frontiers in physiology · 2025Review
- Regulation of tumor metabolism by post translational modifications on metabolic enzymes.Cancer gene therapy · 2023Review
- The Impact of Nicotine along with Oral Contraceptive Exposure on Brain Fatty Acid Metabolism in Female Rats.International journal of molecular sciences · 2022Article
- Extracellular Signal-Regulated Kinase1 (ERK1)-Mediated Phosphorylation of Voltage-Dependent Anion Channel (VDAC) Suppresses its Conductance.The Journal of membrane biology · 2022Article
- VDACs Post-Translational Modifications Discovery by Mass Spectrometry: Impact on Their Hub Function.International journal of molecular sciences · 2021Review
- VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease.Cell calcium · 2021Review
- VDACs: An Outlook on Biochemical Regulation and Function in Animal and Plant Systems.Frontiers in physiology · 2021Review
- Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.Oncotarget · 2015Article
- Markov chain Monte Carlo based analysis of post-translationally modified VDAC gating kinetics.Frontiers in physiology · 2014Article
- Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.American journal of physiology. Heart and circulatory physiology · 2013Article
- Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis.Metabolism: clinical and experimental · 2012Article
- Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components.The Biochemical journal · 2012Article
- Multiple proteins with essential mitochondrial functions have glycosylated isoforms.Mitochondrion · 2012Article
- VDAC inhibition by tubulin and its physiological implications.Biochimica et biophysica acta · 2012Review
- VDAC proteomics: post-translation modifications.Biochimica et biophysica acta · 2012Review
- VDAC1: from structure to cancer therapy.Frontiers in oncology · 2012Article
- Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling.Frontiers in physiology · 2012Article
- An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A.The Journal of biological chemistry · 2011Article
- Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.The Journal of biological chemistry · 2011Article
- Phosphorylation and Acetylation of Acyl-CoA Synthetase- I.Journal of proteomics & bioinformatics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The identification of post-translational modifications is difficult especially for hydrophobic membrane proteins. Here we present the identification of several types of protein modifications on membrane proteins isolated from mitochondrial outer membranes. We show, in vivo, that the mature rat liver mitochondrial carnitine palmitoyltransferase-I enzyme is N-terminally acetylated, phosphorylated on two threonine residues, and nitrated on two tyrosine residues. We show that long chain acyl-CoA synthetase 1 is acetylated at both the N-terminal end and at a lysine residue and tyrosine residues are found to be phosphorylated and nitrated. For the three voltage-dependent anion channel isoforms present in the mitochondria, the N-terminal regions of the protein were determined and sites of phosphorylation were identified. These novel findings raise questions about regulatory aspects of carnitine palmitoyltransferase-I, long chain acyl-CoA synthetase and voltage dependent anion channel and further studies should advance our understanding about regulation of mitochondrial fatty acid oxidation in general and these three proteins in specific.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.