Evidence map›Paper›PMID 17476472›Full record

SynthesisJournal of molecular medicine (Berlin, Germany)2007

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.

Stéphane Cauchi, Younes El Achhab, Hélène Choquet, Christian Dina, Franz Krempler, Raimund Weitgasser, Chakib Nejjari, Wolfgang Patsch, Mohamed Chikri, David Meyre and 1 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of molecular medicine (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 9 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 9 syntheses or guidelines pooled it, 373 citations in OpenAlex.

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  16. Genetic association analysis ofJournal of diabetes and metabolic disorders · 2025
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 4 countries.

Stéphane CauchiCNRS, 8090, Institute of Biology, Pasteur Institute, Lille, 59000, France.
Younes El Achhab
Hélène Choquet
Christian Dina
Franz Krempler
Raimund Weitgasser
Chakib Nejjari
Wolfgang Patsch
Mohamed Chikri
David Meyre
Philippe Froguel
Agence pour le Développement et la Réhabilitation de la Ville de Fès · MACentre National de la Recherche Scientifique · FRInstitut Pasteur de Lille · FRSalzburger Landeskliniken · ATBarmherzige Schwestern Krankenhaus Wien · ATInstitut Pasteur · FRSidi Mohamed Ben Abdellah University · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TCF7L2 variants have been consistently associated with type 2 diabetes (T2D) in populations of different ethnic descent. Among them, the rs7903146 T allele is probably the best proxy to evaluate the effect of this gene on T2D risk in additional ethnic groups. In the present study, we investigated the association between the TCF7L2 rs7903146 polymorphism and T2D in Moroccans (406 normoglycemic individuals and 504 T2D subjects) and in white Austrians (1,075 normoglycemic individuals and 486 T2D subjects). Then, we systematically reviewed the association of this single nucleotide polymorphism (SNP) with T2D risk in a meta-analysis, combining our data with data from previous studies. The allelic odds ratios (ORs) for T2D were 1.56 [1.29-1.89] (p = 2.9 x 10(-6)) and 1.52 [1.29-1.78] (p = 3.0 x 10(-7)) in Moroccans and Austrians, respectively. No heterogeneity was found between these two different populations by Woolf test (chi (2) = 0.04, df = 1, p = 0.84). We found 28 original published association studies dealing with the TCF7L2 rs7903146 polymorphism in T2D. A meta-analysis was then performed on 29,195 control subjects and 17,202 cases. No heterogeneity in genotypic distribution was found (Woolf test: chi (2) = 31.5, df = 26, p = 0.21; Higgins statistic: I2 = 14.1%). A Mantel-Haenszel procedure was then performed to provide a pooled odds ratio (OR) of 1.46 [1.42-1.51] (p = 5.4 x 10(-140)). No publication bias was detected, using the conservative Egger's regression asymmetry test (t = -1.6, df = 25, p = 0.11). Compared to any other gene variants previously confirmed by meta-analysis, TCF7L2 can be distinguished by its tremendous reproducibility of association with T2D and its OR twice as high. In the near future, large-scale genome-wide association studies will fully extend the genome coverage, potentially delivering other common diabetes-susceptibility genes like TCF7L2.

Indexed as

Polymorphism, GeneticAdultAgedCase-Control StudiesDiabetes Mellitus, Type 2EthnicityFemaleGene FrequencyGenotypeHumansMaleMiddle AgedModels, StatisticalOdds RatioTCF Transcription FactorsTranscription Factor 7-Like 2 ProteinTCF7L2 protein, humanTCF Transcription FactorsTranscription Factor 7-Like 2 Protein

Identifiers

PMID17476472
OpenAlexW2114687295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.