ArticleJournal of psychiatry & neuroscience : JPN2007
Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence.
Article in Journal of psychiatry & neuroscience : JPN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence.Human genetics · 2013Pooled it
- Genetic and environmental influences on psychiatric comorbidity: a systematic review.Journal of affective disorders · 2010Pooled it
- Impact of MAOA Gene Polymorphism on the Efficacy of Antidepressant Treatment and Craving Severity for Betel Quid Use Disorder.International journal of molecular sciences · 2024Trial
- Extensive genetic interactions (epistasis) linked to alcohol use disorder in a high-risk population.Communications biology · 2026Article
- Association Between ABCG1/TCF7L2 and Type 2 Diabetes Mellitus: An Intervention Trial Based on a Case-Control Study.Journal of diabetes research · 2025Article
- Polygenic and multi locus heritability of alcoholism: Novel therapeutic targets to overcome psychological deficits.Journal of systems and integrative neuroscience · 2020Article
- The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.Progress in neurobiology · 2020Review
- Incongruent reduction of dopamine transporter availability in different subgroups of alcohol dependence.Medicine · 2016Article
- Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).Molecular neurobiology · 2014Article
- A functional polymorphism of the MAOA gene modulates spontaneous brain activity in pons.BioMed research international · 2014Article
- Polymorphisms of genes in neurotransmitter systems were associated with alcohol use disorders in a Tibetan population.PloS one · 2013Article
- Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems.Recent patents on CNS drug discovery · 2012Article
- The c.1460C>T polymorphism of MAO-A is associated with the risk of depression in postmenopausal women.TheScientificWorldJournal · 2012Article
- Markov model of smoking cessation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Ethical concerns related to developing pharmacogenomic treatment strategies for addiction.Addiction science & clinical practice · 2011Article
- The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review.Clinical psychology review · 2011Review
- Pharmacogenetics: a tool for identifying genetic factors in drug dependence and response to treatment.Addiction science & clinical practice · 2010Review
- Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.BMC medical genetics · 2010Article
- Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation.Alcoholism, clinical and experimental research · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLow monoamine oxidase (MAO) activity and the neurotransmitter dopamine are 2 important factors in the development of alcohol dependence. MAO is an important enzyme associated with the metabolism of biogenic amines. Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.
methodsA total of 427 Han Chinese men in Taiwan (201 control subjects and 226 with alcoholism) were recruited for the study. Of the subjects with alcoholism, 108 had pure alcohol dependence (ALC) and 118 had both alcohol dependence and anxiety, depression or both (ANX/DEP ALC). All subjects were assessed with the Chinese Version of the Modified Schedule of Affective Disorders and Schizophrenia-Lifetime. Alcohol dependence, anxiety and major depressive disorders were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria.
conclusionThe genetic variant of the DRD2 gene was only associated with the ANX/DEP ALC phenotype, and the genetic variant of the MAOA gene was associated with pure ALC. Subjects carrying the MAOA 3-repeat allele and genotype A1/A1 of the DRD2 were 3.48 times (95% confidence interval = 1.47-8.25) more likely to be ANX/DEP ALC than the subjects carrying the MAOA 3-repeat allele and DRD2 A2/A2 genotype. The MAOA gene may modify the association between the DRD2 gene and ANX/DEP ALC phenotype.
Indexed as
Identifiers
17476365PMC1863553W1669711254What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.