ArticlePloS one2007
The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- From polarity to pathology: Decoding the role of cell orientation in osteoarthritis.Journal of orthopaedic translation · 2024Review
- Urinary Collectrin as Promising Biomarker for Acute Kidney Injury in Patients Undergoing Cardiac Surgery.Biomedicines · 2023Article
- Retraction: The Role for HNF-1β-Targeted Collectrin in Maintenance of Primary Cilia and Cell Polarity in Collecting Duct Cells.PloS one · 2023Article
- Urinary Collectrin (TMEM27) as Novel Marker for Acute Kidney Injury.Life (Basel, Switzerland) · 2022Article
- Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?Physiological genomics · 2021Review
- Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.Advances in experimental medicine and biology · 2021Review
- ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection.Biology · 2020Article
- Hepatocyte Nuclear Factor-1Journal of the American Society of Nephrology : JASN · 2017Article
- Expansion of divergent SEA domains in cell surface proteins and nucleoporin 54.Protein science : a publication of the Protein Society · 2017Article
- Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma.Journal of cancer research and clinical oncology · 2016Article
- Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.The Journal of biological chemistry · 2015Article
- Primary cilia and kidney injury: current research status and future perspectives.American journal of physiology. Renal physiology · 2013Review
- Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex.Diabetes · 2012Article
- The pancreatic beta cell surface proteome.Diabetologia · 2012Review
- Angiotensin-converting enzyme 2: the first decade.International journal of hypertension · 2012Article
- Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.Pharmacology & therapeutics · 2010Review
- Not just angiotensinases: new roles for the angiotensin-converting enzymes.Cellular and molecular life sciences : CMLS · 2010Review
- Autosomal dominant polycystic kidney disease: the last 3 years.Kidney international · 2009Review
- The role of the neutral amino acid transporter B0AT1 (SLC6A19) in Hartnup disorder and protein nutrition.IUBMB life · 2009Review
- Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.Molecular endocrinology (Baltimore, Md.) · 2009Article
Corrections and comments
- Retraction · 2023-05-18Concerns/Issues about Results and/or Conclusions · Duplication of/in Image · Error in Image · Error in Text · Manipulation of Images · Unreliable Data ·
- Retracted
Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
Collectrin, a homologue of angiotensin converting enzyme 2 (ACE2), is a type I transmembrane protein, and we originally reported its localization to the cytoplasm and apical membrane of collecting duct cells. Recently, two independent studies of targeted disruption of collectrin in mice resulted in severe and general defects in renal amino acid uptake. Collectrin has been reported to be under the transcriptional regulation by HNF-1alpha, which is exclusively expressed in proximal tubules and localized at the luminal side of brush border membranes. The deficiency of collectrin was associated with reduction of multiple amino acid transporters on luminal membranes. In the current study, we describe that collectrin is a target of HNF-1beta and heavily expressed in the primary cilium of renal collecting duct cells. Collectrin is also localized in the vesicles near the peri-basal body region and binds to gamma-actin-myosin II-A, SNARE, and polycystin-2-polaris complexes, and all of these are involved in intracellular and ciliary movement of vesicles and membrane proteins. Treatment of mIMCD3 cells with collectrin siRNA resulted in defective cilium formation, increased cell proliferation and apoptosis, and disappearance of polycystin-2 in the primary cilium. Suppression of collectrin mRNA in metanephric culture resulted in the formation of multiple longitudinal cysts in ureteric bud branches. Taken together, the cystic change and formation of defective cilium with the interference in the collectrin functions would suggest that it is necessary for recycling of the primary cilia-specific membrane proteins, the maintenance of the primary cilia and cell polarity of collecting duct cells. The transcriptional hierarchy between HNF-1beta and PKD (polycystic kidney disease) genes expressed in the primary cilia of collecting duct cells has been suggested, and collectrin is one of such HNF-1beta regulated genes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.