ArticleThe EMBO journal2007
SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- HSP70 Ameliorates Septic Lung Injury via Inhibition of Apoptosis by Interacting with KANK2.Biomolecules · 2022Article
- PERM1 regulates energy metabolism in the heartFrontiers in cardiovascular medicine · 2022Article
- Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer.Molecular medicine (Cambridge, Mass.) · 2021Article
- Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.Molecular oncology · 2019Article
- Steroid Receptor Coactivator-Interacting Protein (SIP) Suppresses Myocardial Injury Caused by Acute Pancreatitis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis.American journal of cancer research · 2018Article
- Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development.Scientific reports · 2016Article
- ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex.Cell cycle (Georgetown, Tex.) · 2015Article
- ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.Molecular cancer · 2014Article
- RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.The Journal of biological chemistry · 2012Article
- Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria.The Journal of biological chemistry · 2012Article
- ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.Molecular cell · 2012Article
- The histone modifications governing TFF1 transcription mediated by estrogen receptor.The Journal of biological chemistry · 2011Article
- Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity.Molecular endocrinology (Baltimore, Md.) · 2011Article
- CCCTC-binding factor acts upstream of FOXA1 and demarcates the genomic response to estrogen.The Journal of biological chemistry · 2010Article
- sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP.The Journal of biological chemistry · 2010Article
- Keratin 18 attenuates estrogen receptor alpha-mediated signaling by sequestering LRP16 in cytoplasm.BMC cell biology · 2009Article
- ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.The EMBO journal · 2009Article
- Kank proteins: structure, functions and diseases.Cellular and molecular life sciences : CMLS · 2009Review
- The NIMA-family kinase Nek3 regulates microtubule acetylation in neurons.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroid receptor coactivators (SRCs) exert profound effects on animal development and physiology. These coactivators are nuclear proteins and transcription co-regulators that function to facilitate the transcription initiation mediated by nuclear receptors, as well as by other well-known transcription factors. However, how these co-regulators are functionally regulated is poorly understood. During genome-wide screening for SRC-interacting proteins, we identified a novel ankyrin repeat containing protein, SIP (SRC-Interacting Protein), which interacts with SRC coactivators in the cytoplasm. We demonstrated that extracellular stimuli such as the addition of estrogen, induced phosphorylation of SIP in its PEST (Proline, Glutamate, Serine, and Threonine rich) domain by casein kinase II. The phosphorylation of SIP resulted in dissociation of SRC proteins from SIP in the cytoplasm and led to subsequent nuclear translocation of SRC proteins and gene coactivation. Both gain-of-function and loss-of-function experiments indicate that SIP functions to sequester SRC coactivators in the cytoplasm and buffer the availability of these coactivators, thus providing a mechanism for the regulation of the transcription regulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.