ArticleGenes and immunity2007
Genetic linkage analysis of sarcoidosis phenotypes: the sarcoidosis genetic analysis (SAGA) study.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Biomarkers and genetic determinants of cardiac sarcoidosis: current status, the unmet needs and future perspectives.Frontiers in cardiovascular medicine · 2026Review
- Phenotypes and Endotypes in Sarcoidosis: Unraveling Prognosis and Disease Course.Biomedicines · 2025Review
- Fulminant Cardiac Sarcoidosis Successfully Treated With Aggressive Immunosuppressive Therapy.Case reports in cardiology · 2025Article
- Article
- From Karl Wurm and Guy Scadding's staging toFrontiers in medicine · 2023Article
- Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022Review
- Novel HLA associations with outcomes of Mycobacterium tuberculosis exposure and sarcoidosis in individuals of African ancestry using nearest-neighbor feature selection.Genetic epidemiology · 2022Article
- Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.The European respiratory journal · 2021Article
- Genome-Wide Association Study of Ocular Sarcoidosis Confirms HLA Associations and Implicates Barrier Function and Autoimmunity in African Americans.Ocular immunology and inflammation · 2021Article
- Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts.Journal of clinical medicine · 2020Review
- [Artificial intelligence empowers laboratory medicine in Industry 4.0].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Review
- Exome Sequencing Identifies Susceptibility Loci for Sarcoidosis Prognosis.Frontiers in immunology · 2019Article
- Whole-exome sequencing identifies rare genetic variations in German families with pulmonary sarcoidosis.Human genetics · 2018Article
- RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes.Scientific reports · 2017Article
- [Sarcoidosis : Renal manifestations].Zeitschrift fur Rheumatologie · 2017Review
- Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches.Clinics in chest medicine · 2015Review
- Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.Annals of clinical and translational neurology · 2015Article
- [Genetic risk profile of sarcoidosis].Der Internist · 2014Article
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- Neuro-ophthalmic sarcoidosis.Eye and brain · 2012Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The sarcoidosis genetic analysis (SAGA) study previously identified eight chromosomal regions with suggestive evidence for linkage to sarcoidosis susceptibility in African-American sib pairs. Since the clinical course of sarcoidosis is variable and likely under genetic control, we used the affected relative pair portion of the SAGA sample (n=344 pairs) to perform multipoint linkage analyses with covariates based on pulmonary and organ involvement phenotypes. Chest radiographic resolution was the pulmonary phenotype with the highest LOD (logarithm of the backward odds, or likelihood ratio) score of 5.11 at D1S3720 on chromosome 1p36 (P=4 x 10(-5)). In general, higher LOD scores were attained for covariates that modeled clustered organ system involvement rather than individual organ systems, with the cardiac/renal group having the highest LOD score of 6.65 at chromosome 18q22 (P=2 x 10(-5)). The highest LOD scores for the other three organ involvement groups of liver/spleen/bone marrow, neuro/lymph and ocular/skin/joint were 3.72 at 10p11 (P=0.0004), 5.16 at 7p22 (P=4 x 10(-5)) and 2.93 at 10q26 (P=0.001), respectively. Most of the phenotype linkages did not overlap with the regions previously found linked to susceptibility. Our results suggest that genes influencing clinical presentation of sarcoidosis in African Americans are likely to be different from those that underlie disease susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.