ArticleHuman heredity2007
Campora: a young genetic isolate in South Italy.
Article in Human heredity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Moment estimators of relatedness from low-depth whole-genome sequencing data.BMC bioinformatics · 2022Article
- Clinical Network for Big Data and Personalized Health: Study Protocol and Preliminary Results.International journal of environmental research and public health · 2022Article
- Genetics of PlGF plasma levels highlights a role of its receptors and supports the link between angiogenesis and immunity.Scientific reports · 2021Article
- Whole-Exome Sequencing in the Isolated Populations of Cilento from South Italy.Scientific reports · 2019Article
- Article
- Detecting the dominance component of heritability in isolated and outbred human populations.Scientific reports · 2018Article
- Genetic variants modulating CRIPTO serum levels identified by genome-wide association study in Cilento isolates.PLoS genetics · 2015Article
- Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.PloS one · 2013Article
- Small effective population size and genetic homogeneity in the Val Borbera isolate.European journal of human genetics : EJHG · 2013Article
- Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.PloS one · 2011Article
- Comparing population structure as inferred from genealogical versus genetic information.European journal of human genetics : EJHG · 2009Article
- Article
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7 authors.
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Abstract
Genetic isolates have been successfully used in the study of complex traits, mainly because due to their features, they allow a reduction in the complexity of the genetic models underlying the trait. The aim of the present study is to describe the population of Campora, a village in the South of Italy, highlighting its properties of a genetic isolate. Both historical evidence and multi-locus genetic data (genomic and mitochondrial DNA polymorphisms) have been taken into account in the analyses. The extension of linkage disequilibrium (LD) regions has been evaluated on autosomes and on a region of the X chromosome. We defined a study sample population on the basis of the genealogy and exogamy data. We found in this population a few different mitochondrial and Y chromosome haplotypes and we ascertained that, similarly to other isolated populations, in Campora LD extends over wider region compared to large and genetically heterogeneous populations. These findings indicate a conspicuous genetic homogeneity in the genome. Finally, we found evidence for a recent population bottleneck that we propose to interpret as a demographic crisis determined by the plague of the 17th century. Overall our findings demonstrate that Campora displays the genetic characteristics of a young isolate.
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