ArticleMolecular biology of the cell2007
The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 47 citations in OpenAlex.
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- Structural basis for Rab6 activation by the Ric1-Rgp1 complex.Nature communications · 2024Article
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- Structural basis for Rab6 activation by the Ric1-Rgp1 complex.bioRxiv : the preprint server for biology · 2024Article
- Vtc4 Promotes the Entry of Phagophores into Vacuoles in theJournal of fungi (Basel, Switzerland) · 2023Article
- The entry of unclosed autophagosomes into vacuoles and its physiological relevance.PLoS genetics · 2022Article
- Vps21 Directs the PI3K-PI(3)P-Atg21-Atg16 Module to Phagophores via Vps8 for Autophagy.International journal of molecular sciences · 2022Article
- Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32.Science advances · 2022Article
- Arf1 orchestrates Rab GTPase conversion at theMolecular biology of the cell · 2021Article
- Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII.PLoS genetics · 2019Article
- The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis.The Journal of biological chemistry · 2019Article
- Ypt/Rab GTPases and their TRAPP GEFs at the Golgi.FEBS letters · 2019Review
- Rab5-dependent autophagosome closure by ESCRT.The Journal of cell biology · 2019Article
- The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae.Molecules and cells · 2017Article
- A Rab5 GTPase module is important for autophagosome closure.PLoS genetics · 2017Article
- COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.The EMBO journal · 2017Article
- TRAPP Complexes in Secretion and Autophagy.Frontiers in cell and developmental biology · 2016Review
- Ypt/Rab GTPases: principles learned from yeast.Critical reviews in biochemistry and molecular biology · 2015Review
- A Vps21 endocytic module regulates autophagy.Molecular biology of the cell · 2014Article
- Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.Traffic (Copenhagen, Denmark) · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The conserved modular complex TRAPP is a guanine nucleotide exchanger (GEF) for the yeast Golgi Ypt-GTPase gatekeepers. TRAPP I and TRAPP II share seven subunits and act as GEFs for Ypt1 and Ypt31/32, respectively, which in turn regulate transport into and out of the Golgi. Trs65/Kre11 is one of three TRAPP II-specific subunits. Unlike the other two subunits, Trs120 and Trs130, Trs65 is not essential for viability, is conserved only among some fungi, and its contribution to TRAPP II function is unclear. Here, we provide genetic, biochemical, and cellular evidence for the role of Trs65 in TRAPP II function. First, like Trs130, Trs65 localizes to the trans-Golgi. Second, TRS65 interacts genetically with TRS120 and TRS130. Third, Trs65 interacts physically with Trs120 and Trs130. Finally, trs65 mutant cells have low levels of Trs130 protein, and they are defective in the GEF activity of TRAPP II and the intracellular distribution of Ypt1 and Ypt31/32. Together, these results show that Trs65 plays a role in the Ypt GEF activity of TRAPP II in concert with the two other TRAPP II-specific subunits. Elucidation of the role played by Trs65 in intracellular trafficking is important for understanding how this process is coordinated with two other processes in which Trs65 is implicated: cell wall biogenesis and stress response.
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