ArticleThe British journal of ophthalmology2007
Reduced expression of autotaxin predicts survival in uveal melanoma.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Dual role of autotaxin as novel biomarker and therapeutic target in pancreatic neuroendocrine neoplasms.Cancer science · 2023Article
- Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers.Investigative ophthalmology & visual science · 2023Article
- Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner.International journal of molecular sciences · 2023Article
- Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma.Metabolites · 2021Article
- BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities.The Journal of pathology · 2019Review
- Are Risk Factors for Growth of Choroidal Nevi Associated With Malignant Transformation? Assessment With a Validated Genomic Biomarker.American journal of ophthalmology · 2019Article
- Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.JAMA ophthalmology · 2016Article
- Prognostic Implications of Tumor Diameter in Association With Gene Expression Profile for Uveal Melanoma.JAMA ophthalmology · 2016Observational
- Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Bioorganic & medicinal chemistry · 2015Article
- Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.Ophthalmology · 2012Article
- Blood biomarkers for uveal melanoma.Future oncology (London, England) · 2012Review
- Uveal melanoma: the inflammatory microenvironment.Journal of innate immunity · 2012Review
- Autotaxin: its role in biology of melanoma cells and as a pharmacological target.Enzyme research · 2011Article
- An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma.The Journal of molecular diagnostics : JMD · 2010Article
- Expression profiling of formalin-fixed paraffin embedded primary human uveal melanomas using DASL matrices.Journal of cancer research and clinical oncology · 2010Article
- Article
- Autotaxin.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality.
methodsThe RNA was isolated from 27 samples of uveal melanoma from patients who had consented to undergo enucleation, and transcripts profiled using a cDNA array comprised of sequence-verified cDNA clones representing approximately 4000 genes implicated in cancer development. Two multivariate data mining techniques--hierarchical cluster analysis and multidimensional scaling--were used to investigate the grouping structure in the gene expression data. Cluster analysis was performed with a subset of 10,000 randomly selected genes and the cumulative contribution of all the genes in making the correct grouping was recorded.
resultsHierarchical cluster analysis and multidimensional scaling revealed two distinct classes. When correlated with the data on metastasis, the two molecular classes corresponded very well to the survival data for the 27 patients. Thirty two discrete genes (corresponding to 44 probe sets) that correctly defined the molecular classes were selected. A single gene (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxin) could classify the molecular types. The expression pattern was confirmed using real-time quantitative PCR.
conclusionsGene expression profiling identifies two distinct prognostic classes of uveal melanoma. Underexpression of autotaxin in class 2 uveal melanoma with a poor prognosis needs to be explored further.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.