ReviewNeural development2007
Drosophila as a genetic and cellular model for studies on axonal growth.
Review in Neural development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish.PLoS biology · 2026Article
- Article
- AiScience · 2023Article
- Activating RAC1 variants in the switch II region cause a developmental syndrome and alter neuronal morphology.Brain : a journal of neurology · 2022Article
- Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice.Environmental science and pollution research international · 2022Article
- Looking at Developmental Neurotoxicity Testing from the Perspective of an Invertebrate Embryo.International journal of molecular sciences · 2022Review
- Drosophila Primary Neuronal Cultures as a Useful Cellular Model to Study and Image Axonal Transport.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Macrophages and Their Organ Locations Shape Each Other in Development and Homeostasis - AFrontiers in cell and developmental biology · 2021Review
- UsingDevelopment (Cambridge, England) · 2020Review
- Article
- The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology.Neural development · 2019Review
- Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- Vesicular Axonal Transport is Modified In Vivo by Tau Deletion or Overexpression in Drosophila.International journal of molecular sciences · 2018Article
- Dissection and Immunofluorescent Staining of Mushroom Body and Photoreceptor Neurons in Adult Drosophila melanogaster Brains.Journal of visualized experiments : JoVE · 2017Article
- Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord.Scientific reports · 2017Article
- Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.Journal of cell science · 2016Article
- Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.Molecular biology of the cell · 2015Article
- The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.Neural development · 2013Review
- How to design a genetic mating scheme: a basic training package for Drosophila genetics.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
One of the most fascinating processes during nervous system development is the establishment of stereotypic neuronal networks. An essential step in this process is the outgrowth and precise navigation (pathfinding) of axons and dendrites towards their synaptic partner cells. This phenomenon was first described more than a century ago and, over the past decades, increasing insights have been gained into the cellular and molecular mechanisms regulating neuronal growth and navigation. Progress in this area has been greatly assisted by the use of simple and genetically tractable invertebrate model systems, such as the fruit fly Drosophila melanogaster. This review is dedicated to Drosophila as a genetic and cellular model to study axonal growth and demonstrates how it can and has been used for this research. We describe the various cellular systems of Drosophila used for such studies, insights into axonal growth cones and their cytoskeletal dynamics, and summarise identified molecular signalling pathways required for growth cone navigation, with particular focus on pathfinding decisions in the ventral nerve cord of Drosophila embryos. These Drosophila-specific aspects are viewed in the general context of our current knowledge about neuronal growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.