ArticleBiochemistry2007
Large disk intermediate precedes formation of apolipoprotein A-I-dimyristoylphosphatidylcholine small disks.
Article in Biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- The low-resolution structure of nHDL reconstituted with DMPC with and without cholesterol reveals a mechanism for particle expansion.Journal of lipid research · 2013Article
- Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I.Biochimica et biophysica acta · 2011Article
- Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III.PloS one · 2010Article
- High density lipoprotein structure-function and role in reverse cholesterol transport.Sub-cellular biochemistry · 2010Review
- Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis.Thrombosis research · 2009Article
- Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I.Biochimica et biophysica acta · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Small approximately 8.5 nm disks formed spontaneously when dimyristoylphosphatidylcholine (DMPC) large unilamellar vesicles (LUVs) were incubated with apolipoprotein A-I (apoA-I) (100:1 molar ratio). However, in a time course study, the transient production of approximately 11 nm large disks was detected and isolated by gel filtration. The intermediate large disks contained three apoA-I molecules and were stable over time; however, when additional apoA-I was added, they formed small disks containing two molecules of apoA-I. The reaction kinetics of apoA-I with DMPC LUVs was monitored by fluorescence resonance energy transfer, and two phases were observed, supporting the presence of the intermediate in the formation of small disks. The lipid dynamics of LUVs and disks were assayed, revealing the presence of sequestered lipid-protein domains upon apoA-I binding to DMPC LUVs. In addition, the lipids in the intermediate large disks were more constrained than those in the small disks. We propose that apoA-I binds with DMPC LUVs to form small lipid-protein domains on the LUV; then the domains are released to form large disks, which can mature in the presence of additional apoA-I to form small disks. Thus, the formation of small apoA-I lipid disks proceeds through the formation of a large disk intermediate.
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