ReviewPflugers Archiv : European journal of physiology2007
Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains.
Review in Pflugers Archiv : European journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Acute diacylglycerol production activates critical membrane-shaping proteins leading to mitochondrial tubulation and fission.Nature communications · 2025Article
- Capture at the ER-mitochondrial contacts licenses IPNature communications · 2022Article
- Expression of a membrane-targeted fluorescent reporter disrupts auditory hair cell mechanoelectrical transduction and causes profound deafness.Hearing research · 2021Article
- Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures.Nature communications · 2019Article
- Redox regulation of ER and mitochondrial CaCell calcium · 2019Review
- Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by HFree radical biology & medicine · 2019Article
- Quantifying lipid changes in various membrane compartments using lipid binding protein domains.Cell calcium · 2017Review
- Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated CaScientific reports · 2016Article
- Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface.Molecular cell · 2016Article
- The role of myosin 1c and myosin 1b in surfactant exocytosis.Journal of cell science · 2016Article
- Lamellipodin Is Important for Cell-to-Cell Spread and Actin-Based Motility in Listeria monocytogenes.Infection and immunity · 2015Article
- Cholesterol stabilizes fluid phosphoinositide domains.Chemistry and physics of lipids · 2014Article
- Rapidly relocating molecules between organelles to manipulate small GTPase activity.ACS chemical biology · 2012Article
- Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor.Journal of cell science · 2012Article
- Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.PLoS genetics · 2012Article
- Acute manipulation of phosphoinositide levels in cells.Methods in cell biology · 2012Article
- Microtubules support a disk-like septin arrangement at the plasma membrane of mammalian cells.Molecular biology of the cell · 2011Article
- Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors.The Journal of biological chemistry · 2011Article
- Optical probing of a dynamic membrane interaction that regulates the TREK1 channel.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Phosphoinositides: lipid regulators of membrane proteins.The Journal of physiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
There is hardly a membrane-associated molecular event that is not regulated by phosphoinositides, a minor but critically important class of phospholipids of cellular membranes. The rapid formation, elimination, and conversion of these lipids in specific membrane compartments are ensured by a wealthy number of inositol lipid kinases and phosphatases with unique localization and regulatory properties. The existence of multiple inositol lipid pools have been indicated by metabolic labeling studies, but the level of functional compartmentalization revealed by the identification of numerous protein effectors acted upon by phosphoinositides could not have been foreseen. The changing perception of inositides from just serving as lipid precursors of second messengers to becoming highly dynamic local membrane-bound regulators poses new challenges concerning the detection of their rapid localized changes. Moreover, it is increasingly evident that manipulation of lipids in highly defined compartments would be a highly superior approach to soaking the cells with a particular phosphoinositide when studying the local regulation of the lipid on any effectors. In this review, we will summarize our efforts to improve our tools in studying phosphoinositide dynamics and discuss our views on the values of these methods compared to other options currently used or being explored.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.