Trial reportBritish journal of sports medicine2007
Effect of caffeine supplementation on haematological and biochemical variables in elite soccer players under physical stress conditions.
Trial report in British journal of sports medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Effect of Caffeine Ingestion on Indirect Markers of Exercise-Induced Muscle Damage: A Systematic Review of Human Trials.Nutrients · 2022Pooled it
- Caffeine Supplementation and Physical Performance, Muscle Damage and Perception of Fatigue in Soccer Players: A Systematic Review.Nutrients · 2019Pooled it
- Effects of Caffeine Supplementation on Physical Performance of Soccer Players: Systematic Review and Meta-Analysis.Sports healthPooled it
- Melatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.Nutrients · 2026Trial
- The Effect of Acute Caffeine Intake on Resistance Training Volume, Prooxidant-Antioxidant Balance and Muscle Damage Markers Following a Session of Full-Body Resistance Exercise in Resistance-Trained Men Habituated to Caffeine.Journal of sports science & medicine · 2023Trial
- Carbohydrate supplementation delays DNA damage in elite runners during intensive microcycle training.European journal of applied physiology · 2012Trial
- Modulatory Effects of Caffeine on Imatinib Binding: A Molecular Docking Study Targeting CYP3A4.Life (Basel, Switzerland) · 2025Article
- The Influence of Competition Day Loads on the Metabolic and Immune Response of Olympic Female Beach Volleyball Athletes: A Sportomics Analysis.Nutrients · 2025Article
- Article
- Factors influencing peripheral immunity and its links to brain disorders.Translational psychiatry · 2024Article
- Biomarkers of post-match recovery in semi-professional and professional football (soccer).Frontiers in physiology · 2023Review
- Review
- Dose caffeinated energy drink is a consideration issue for endurance performance.Frontiers in physiology · 2022Article
- Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review.Purinergic signalling · 2021Review
- Hematological parameters in champion of Brazilian jiu-jitsu paradesport: Case study.Physiological reports · 2020Article
- Effectiveness of Grounded Sleeping on Recovery After Intensive Eccentric Muscle Loading.Frontiers in physiology · 2019Article
- Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach.Nutrients · 2016Article
- Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners.European journal of applied physiology · 2013Article
- Identification of serum analytes and metabolites associated with aerobic capacity.European journal of applied physiology · 2013Article
- A sportomics strategy to analyze the ability of arginine to modulate both ammonia and lymphocyte levels in blood after high-intensity exercise.Journal of the International Society of Sports Nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of caffeine on white cell distribution and muscle injury markers in professional soccer players during exercise.
methods22 male athletes completed a placebo controlled double blind test protocol to simulate a soccer match, followed by a Yo-Yo intermittent recovery test.
resultsExercise caused an increase in packed cell volume that was enhanced by caffeine. Caffeine and exercise had a synergistic effect on the blood lymphocyte count, which increased by about 38% after exercise, and by an additional 35% when combined with caffeine. Caffeine promoted an exercise independent rise in circulating monocytes, and a synergistic action of exercise and caffeine was observed on segmented neutrophils. Caffeine promoted thrombocytosis. Plasma adenosine deaminase, aspartate aminotransferase, and lactate dehydrogenase concentrations were enhanced by exercise, and alanine transaminase concentration was enhanced in both groups, with a synergistic effect of caffeine.
conclusionsThe pronounced increase in the white cell count in the group receiving caffeine appeared to be caused by greater muscle stress and consequently more intense endothelial and muscle cell injury. The use of caffeine may augment the risk of muscle damage in athletes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.