ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2007
Coevolution of metabolic networks and membranes: the scenario of progressive sequestration.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- From experimental clues to theoretical modeling: Evolution associated with the membrane-takeover at an early stage of life.PLoS computational biology · 2025Article
- The Origin(s) of LUCA: Computer Simulation of a New Theory.Life (Basel, Switzerland) · 2025Article
- Evolution of Cellular Organization Along the First Branches of the Tree of Life.Journal of molecular evolution · 2024Article
- 2020 Zuckerkandl Prize.Journal of molecular evolution · 2021Article
- The requirement of cellularity for abiogenesis.Computational and structural biotechnology journal · 2021Review
- The Coevolution of Cellularity and Metabolism Following the Origin of Life.Journal of molecular evolution · 2020Article
- Dynamics and stability in prebiotic information integration: an RNA World model from first principles.Scientific reports · 2020Article
- Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.Scientific reports · 2017Article
- Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research.Beilstein journal of organic chemistry · 2017Article
- In silico ribozyme evolution in a metabolically coupled RNA population.Biology direct · 2015Article
- Early evolution of efficient enzymes and genome organization.Biology direct · 2012Article
- Open questions on the origin of life at anoxic geothermal fields.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Article
- The role of energy in the emergence of biology from chemistry.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Article
- Origin of first cells at terrestrial, anoxic geothermal fields.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.PloS one · 2012Article
- The evolution of enzyme specificity in the metabolic replicator model of prebiotic evolution.PloS one · 2011Article
- Beneficial laggards: multilevel selection, cooperative polymorphism and division of labour in threshold public good games.BMC evolutionary biology · 2010Article
- Membrane transport in primitive cells.Cold Spring Harbor perspectives in biology · 2010Review
- The role of the formamide/zirconia system in the synthesis of nucleobases and biogenic carboxylic acid derivatives.Journal of molecular evolution · 2010Article
- The origin of life: chemical evolution of a metabolic system in a mineral honeycomb?Journal of molecular evolution · 2009Article
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1 author.
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Abstract
Many regard metabolism as one of the central phenomena (or criteria) of life. Yet, the earliest infrabiological systems may have been devoid of metabolism: such systems would have been extreme heterotrophs. We do not know what level of complexity is attainable for chemical systems without enzymatic aid. Lack of template-instructed enzymatic catalysis may put a ceiling on complexity owing to inevitable spontaneous decay and wear and tear of chemodynamical machines. Views on the origin of metabolism critically depend on the assumptions concerning the sites of synthesis and consumption of organic compounds. If these sites are different, non-enzymatic origin of autotrophy is excluded. Whether autotrophy is secondary or not, it seems that protocell boundaries may have become more selective with time, concurrent with the enzymatization of the metabolic network. Primary heterotrophy and autotrophy imply pathway innovation and retention, respectively. The idea of metabolism-membrane coevolution leads to a scenario of progressive sequestration of the emerging living system from its exterior milieu. Comparative data on current protein enzymes may shed some light on such a primeval process by analogy, since two main ideas about enzymatization (the retroevolution and the patchwork scenarios) may not necessarily be mutually exclusive and the earliest enzymatic system may have used ribozymes rather than proteins.
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