ArticleThe Biochemical journal2007
Multidrug resistance-associated protein 9 (ABCC12) is present in mouse and boar sperm.
Article in The Biochemical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
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- Drug Transporters at the Human Blood-Testis Barrier.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies.Antioxidants (Basel, Switzerland) · 2023Review
- The chromosome-scale genome of the raccoon dog: Insights into its evolutionary characteristics.iScience · 2022Article
- MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Kyoto probe-1 reveals phenotypic differences between mouse ES cells and iTS-P cells.Scientific reports · 2020Article
- Prognostic significance and molecular mechanisms of adenosine triphosphate-binding cassette subfamily C members in gastric cancer.Medicine · 2019Article
- Control of metazoan heme homeostasis by a conserved multidrug resistance protein.Cell metabolism · 2014Article
- ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation.Biology of reproduction · 2012Article
- Multidrug resistance associated proteins in multidrug resistance.Chinese journal of cancer · 2012Review
- Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion.Frontiers in genetics · 2012Article
- Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.The FEBS journal · 2011Review
- Drug transporters, the blood-testis barrier, and spermatogenesis.The Journal of endocrinology · 2011Review
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.The international journal of biochemistry & cell biology · 2009Article
- Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.Antimicrobial agents and chemotherapy · 2009Article
- Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities.Antioxidants & redox signaling · 2009Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human and murine genes for MRP9 (multidrug resistance-associated protein 9; ABCC12) yield many alternatively spliced RNAs. Using a panel of monoclonal antibodies, we detected full-length Mrp9 only in testicular germ cells and mouse sperm; we obtained no evidence for the existence of the truncated 100 kDa MRP9 protein reported previously. In contrast with other MRPs, neither murine Mrp9 nor the human MRP9 produced in MRP9-transfected HEK-293 cells (human embryonic kidney cells) appears to contain N-linked carbohydrates. In mouse and boar sperm, Mrp9 localizes to the midpiece, a structure containing all sperm mitochondria. However, immunolocalization microscopy and cell fractionation studies with transfected HEK-293 cells and mouse testis show that MRP9/Mrp9 does not localize to mitochondria. In HEK-293 cells, it is predominantly localized in the endoplasmic reticulum. We have been unable to demonstrate transport by MRP9 of substrates transported by other MRPs, such as drug conjugates and other organic anions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.