ArticleMolecular psychiatry2008
Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.
Article in Molecular psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.
- DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review.BMC genetics · 2016Pooled it
- Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins.Epigenomes · 2024Article
- Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.Innovation (Cambridge (Mass.)) · 2023Article
- Article
- Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9.Nature communications · 2021Article
- Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety.Scientific reports · 2021Article
- Effect of adverse childhood experiences and DNA methylation on male sexual orientation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Association of Epigenetic Differences Screened in a Few Cases of Monozygotic Twins Discordant for Attention-Deficit Hyperactivity Disorder With Brain Structures.Frontiers in neuroscience · 2021Article
- Methylation Patterns of theFrontiers in psychiatry · 2020Article
- miRNA-210-3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction.Journal of cellular and molecular medicine · 2019Article
- Sleep Disturbance in Bipolar Disorder: Neuroglia and Circadian Rhythms.Frontiers in psychiatry · 2019Review
- Paternal germ line aging: DNA methylation age prediction from human sperm.BMC genomics · 2018Article
- Differentially Methylated Genes in Saliva are linked to Childhood Stress.Scientific reports · 2018Article
- A multi-dimensional characterization of anxiety in monozygotic twin pairs reveals susceptibility loci in humans.Translational psychiatry · 2017Article
- Article
- Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder.Neural plasticity · 2017Review
- Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress.Neurobiology of disease · 2016Article
- Making Sense of Epigenetics.The international journal of neuropsychopharmacology · 2016Review
- Dissecting bipolar disorder complexity through epigenomic approach.Molecular psychiatry · 2016Review
- The role of DNA methylation in the pathophysiology and treatment of bipolar disorder.Neuroscience and biobehavioral reviews · 2016Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA) to lymphoblastoid cells derived from the twins. MS-RDA isolated 10 DNA fragments derived from 5' region of known genes/ESTs. Among these 10 regions, four regions showed DNA methylation differences between bipolar twin and control co-twin confirmed by bisulfite sequencing. We performed a case-control study of DNA methylation status of these four regions by pyrosequencing. Two regions, upstream regions of spermine synthase (SMS) and peptidylprolyl isomerase E-like (PPIEL) (CN265253), showed aberrant DNA methylation status in bipolar disorder. SMS, a gene on X chromosome, showed significantly higher DNA methylation level in female patients with bipolar disorder compared with control females. However, there was no difference of mRNA expression. In PPIEL, DNA methylation level was significantly lower in patients with bipolar II disorder than in controls. The expression level of PPIEL was significantly higher in bipolar II disorder than in controls. We found strong inverse correlation between gene expression and DNA methylation levels of PPIEL. These results suggest that altered DNA methylation statuses of PPIEL might have some significance in pathophysiology of bipolar disorder..
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