ReviewBritish journal of pharmacology2007
Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties.
Review in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 1 synthesis or guideline pooled it, 346 citations in OpenAlex.
- Albumin levels in malaria patients: a systematic review and meta-analysis of their association with disease severity.Scientific reports · 2024Pooled it
- Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality.Scientific reports · 2021Trial
- Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications.Redox report : communications in free radical research · 2026Review
- [Focus on Albumin: new perspectives for the clinical application in intensive care medicine : From the quantitative routine to qualitative individualized theranostics].Die Anaesthesiologie · 2026Review
- Albumin redox status in the context of kidney transplantation - an observational, pilot study.BMC nephrology · 2026Observational
- Serum nonmercaptalbumin to total albumin ratio and bilirubin predict ADL decline in older adults with type 2 diabetes.Journal of diabetes investigation · 2026Article
- Prognostic Value of Albumin/Globulin Ratio for Mortality in Stage 2 Cardiovascular-Kidney-Metabolic Syndrome: A Nationwide Cohort Analysis (1999-2018).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Review
- Construction of a predictive model for the risk of non-alcoholic fatty liver disease in patients with sleep apnea syndrome based on multiple machine learning algorithms: a multicenter study.BMC medical informatics and decision making · 2026Article
- The Differential Redox Resilience of Alvelestat and Sivelestat: A Mechanistic Hypothesis for Inhibitor Performance Under Oxidative Stress.Molecules (Basel, Switzerland) · 2026Article
- Use of Human Serum Albumin CysAntioxidants (Basel, Switzerland) · 2026Review
- Creatinine-to-albumin ratio for early ICU-course (first 24 hours) risk stratification of mortality in critically ill patients with gastrointestinal bleeding: A retrospective cohort study.Science progress · 2026Article
- Modulation of islet amyloid polypeptide induced β-cell toxicity and amyloid formation by serum albumin proteins.Biophysical chemistry · 2026Article
- Article
- Risk factors analysis and nomogram model construction of refeeding syndrome after esophageal cancer surgery.Frontiers in oncology · 2026Article
- Predictive value of fibrinogen-to-albumin ratio in early missed miscarriage: a case-control study.Frontiers in medicine · 2026Article
- Fingertip skin autofluorescence as a non-invasive marker for vascular complications in patients with type 2 diabetes.Journal of diabetes investigation · 2025Article
- Oxidative and Glycation Stress Biomarkers: Advances in Detection Technologies and Point-of-Care Clinical Applications.Molecules (Basel, Switzerland) · 2025Review
- Albumin as a natural and moldable biomaterial for biomimetic drug delivery applications.International journal of pharmaceutics · 2025Review
- Declining Serum Albumin With Stable Body Mass Index: A Mortality Indicator in Predialysis Chronic Kidney Disease.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2025Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Binding and transport of a number of endogenous and exogenous compounds is an important function of the main plasma protein, albumin. In vivo and in vitro, albumin may be oxidatively modified in different ways with different agents at different sites. These modifications have various consequences on the physiological functions of albumin. Diabetes mellitus, liver diseases and nephropathy are just a few examples of disorders in which oxidative stress is involved and altered albumin functions have been described. This review is focussed on the consequences of oxidative modification on the binding properties of albumin. These range from no effect to decreased or increased binding affinities depending on the ligand under investigation and the type of modification. Indicators for modification include glycosylation, disulphide formation or the content of carbonyl groups. The redox state of albumin can affect the binding properties in several ways, including altered conformation and consequently altered affinities at binding sites and altered binding when the binding reaction itself is redox sensitive. The physiological or pathophysiological concentrations of different oxidatively modified albumin molecules vary over a wide range and are crucial in assessing the clinical relevance of altered ligand binding properties of a particularly modified albumin species in various disease conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.