ArticleBiochemical genetics1991
Biochemical and physiological studies of soluble esterases from Drosophila melanogaster.
Article in Biochemical genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bioactivation and detoxification of organophosphorus pesticides in freshwater planarians shares similarities with humans.Archives of toxicology · 2022Article
- Fitness differences due to allelic variation at Esterase-4 locus in Drosophila ananassae.Journal of genetics · 2017Article
- Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila.BMC biology · 2012Article
- Purification and characterization of carboxylesterase from the seeds of Jatropha curcas.The protein journal · 2012Article
- Variability of esterase patterns in adult flies of the saltans species group of Drosophila (subgenus Sophophora).Genetica · 2009Article
- Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.The Journal of clinical investigation · 2008Article
- A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee.Insect molecular biology · 2006Article
- Article
- Molecular population genetics of the beta-esterase gene cluster of Drosophila melanogaster.Journal of genetics · 2003Article
- Article
- Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster.Journal of molecular evolution · 1996Article
- Mutational analysis of N-linked glycosylation of esterase 6 in Drosophila melanogaster.Biochemical genetics · 1996Article
- Article
- A cluster of at least three esterase genes in Lucilia cuprina includes malathion carboxylesterase and two other esterases implicated in resistance to organophosphates.Biochemical genetics · 1994Article
- A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina.Biochemical genetics · 1994Article
- Associations of esterase 6 allozyme and activity variation with reproductive fitness in Drosophila melanogaster.Genetica · 1994Article
- Localization of sequences controlling the spatial, temporal, and sex-specific expression of the esterase 6 locus in Drosophila melanogaster adults.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Evolutionary genetics of Drosophila esterases.Genetica · 1993Review
- Genetics of the hemolymph esterases of Lucilia cuprina (Diptera: Calliphoridae).Biochemical genetics · 1992Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-two soluble esterases have been identified in D. melanogaster by combining the techniques of native polyacrylamide gel electrophoresis and isoelectric focusing. The sensitivity of each isozyme to three types of inhibitors (organophosphates, eserine sulfate, and sulfydryl reagents) identified 10 as carboxylesterases, 6 as cholinesterases, and 3 as acetylesterases. Three isozymes could not be classified and no arylesterases were identified. The carboxyl- and cholinesterases could each be further divided into two subclasses on the basis of inhibition by organophosphates and sulfhydryl reagents, respectively. Choline- and acetylesterases have characteristic substrate preferences but both subclasses of carboxylesterases are heterogeneous in substrate utilization. Subclass 2 carboxylesterases exhibit diverse temporal expression patterns, with subclass 1 carboxylesterases generally found in larvae and subclass 1 cholinesterases and acetylesterases more characteristic of pupae and adults. Tissues showing the greatest number of isozymes are larval body wall (eight) and digestive tract (six in larvae, six in adults). Carboxylesterases are distributed across a wide range of tissues, but subclass 1 cholinesterases are generally associated with neural or neurosecretory tissues and subclass 2 cholinesterases with digestive tissues.
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