ReviewAnnals of the New York Academy of Sciences2007
Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms.
Review in Annals of the New York Academy of Sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles.Journal of biological engineering · 2023Article
- Purslane (Portulaca oleracea L.) as a novel green-bioreactor for expression of human serum albumin (HSA) gene.Transgenic research · 2022Article
- Recombinant Protein Production and Purification of Insoluble Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The case for biotech on Mars.Nature biotechnology · 2020Article
- Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells.Frontiers in plant science · 2015Article
- The potential of transgenic green microalgae; a robust photobioreactor to produce recombinant therapeutic proteins.World journal of microbiology & biotechnology · 2014Review
- Production of pharmaceutical proteins in solanaceae food crops.International journal of molecular sciences · 2013Article
- Article
- Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules.Plant biotechnology journal · 2012Review
- Chlamydomonas reinhardtii as a viable platform for the production of recombinant proteins: current status and perspectives.Plant cell reports · 2012Review
- Stable plastid transformation for high-level recombinant protein expression: promises and challenges.Journal of biomedicine & biotechnology · 2012Article
- Expression and subcellular targeting of human complement factor C5a in Nicotiana species.PloS one · 2012Article
- The development, characterization, and demonstration of a novel strategy for purification of recombinant proteins expressed in plants.Transgenic research · 2011Article
- Molecular factors affecting the accumulation of recombinant proteins in the Chlamydomonas reinhardtii chloroplast.Molecular biotechnology · 2011Article
- High-yield expression of recombinant soybean agglutinin in plants using transient and stable systems.Transgenic research · 2011Article
- Article
- Expression of a ricin toxin B subunit: insulin fusion protein in edible plant tissues.Molecular biotechnology · 2010Article
- A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65).BMC biotechnology · 2008Article
- Transgenic tomato expressing interleukin-12 has a therapeutic effect in a murine model of progressive pulmonary tuberculosis.Clinical and experimental immunology · 2008Article
- Plant-derived EpCAM antigen induces protective anti-cancer response.Cancer immunology, immunotherapy : CII · 2008Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, the technique to genetically modify crop plants has gained more and more interest in terms of bioproduction of heterologous proteins. Plants have been discovered as a possible source for large amounts of cost effective recombinant protein. Main application fields are therapeutics for use in animal and human health, diagnostics, and technical enzymes. This review is focused on the recent progress in this field of molecular farming. After a comparison with hitherto established protein production systems, the advantages of plants as an alternative production system are discussed. An overview about the different host plants and possible expression strategies is given and the progress in commercialization of the techniques is highlighted. Finally, the role of plant cell cultures for the production of recombinant proteins is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.