ArticleProceedings of the National Academy of Sciences of the United States of America2007
Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- LysR-type regulator LrhA promotes CRISPR-Cas immunity in Escherichia coli.Nucleic acids research · 2026Article
- Segregation of sister chromosomes during the shape change of developingJournal of bacteriology · 2025Article
- Article
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch.PLoS genetics · 2018Article
- Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR.Scientific reports · 2016Article
- Genetic dissection of independent and cooperative transcriptional activation by the LysR-type activator ThnR at close divergent promoters.Scientific reports · 2016Article
- devI is an evolutionarily young negative regulator of Myxococcus xanthus development.Journal of bacteriology · 2015Article
- Combinatorial regulation of the dev operon by MrpC2 and FruA during Myxococcus xanthus development.Journal of bacteriology · 2015Article
- Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus.BMC genomics · 2014Article
- Nutrient-regulated proteolysis of MrpC halts expression of genes important for commitment to sporulation during Myxococcus xanthus development.Journal of bacteriology · 2014Article
- Fatty acids from membrane lipids become incorporated into lipid bodies during Myxococcus xanthus differentiation.PloS one · 2014Article
- The Nla28S/Nla28 two-component signal transduction system regulates sporulation in Myxococcus xanthus.Journal of bacteriology · 2012Article
- Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis.Journal of bacteriology · 2012Article
- Combinatorial regulation by MrpC2 and FruA involves three sites in the fmgE promoter region during Myxococcus xanthus development.Journal of bacteriology · 2011Article
- Combinatorial regulation of fmgD by MrpC2 and FruA during Myxococcus xanthus development.Journal of bacteriology · 2011Article
- Myxobacteria, polarity, and multicellular morphogenesis.Cold Spring Harbor perspectives in biology · 2010Review
- Combinatorial regulation by a novel arrangement of FruA and MrpC2 transcription factors during Myxococcus xanthus development.Journal of bacteriology · 2009Article
- A combination of unusual transcription factors binds cooperatively to control Myxococcus xanthus developmental gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Chemotaxis as an emergent property of a swarm.Journal of bacteriology · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myxococcus xanthus is a bacterium that undergoes multicellular development. C-signaling influences gene expression and movement of cells into aggregates. Expression of the dev operon, which includes genes essential for efficient sporulation, depends in part on C-signaling and reaches its highest level in cells within aggregates, ensuring that spores form within fruiting bodies. Here, an upstream DNA element was found to be essential for dev promoter activity and was bound by FruA, a response regulator in the C-signaling pathway. A second positive regulatory element, located approximately 350 bp downstream of the dev transcriptional start site, was bound by LadA, a newly identified transcription factor in the LysR family. Typically, LysR-type transcription factors bind upstream of the promoter and activate transcription in response to a coinducer. LadA appears to activate transcription from an unusual location for a LysR family member and likely subjects dev transcription to a different cue than does FruA. A ladA mutant exhibited similar developmental defects as dev mutants, suggesting that LadA may be devoted to dev regulation, unlike FruA, which regulates many developmental genes. FruA and LadA act on a regulatory region spanning >400 bp to bring about proper temporal and spatial expression of the dev operon, resembling the regulation of developmental genes in multicellular eukaryotes.
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