ArticleProceedings of the National Academy of Sciences of the United States of America2007
An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
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- Rethinking asexuality: the enigmatic case of functional sexual genes in Lepraria (Stereocaulaceae).BMC genomics · 2024Article
- The serine/threonine protein kinase MpSTE1 directly governs hyphal branching in Monascus spp.Applied microbiology and biotechnology · 2024Article
- Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- The COP9 signalosome complex regulates fungal development and virulence in the wheat scab fungusFrontiers in microbiology · 2023Article
- Article
- F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans.PLoS genetics · 2022Article
- The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis.Nucleic acids research · 2022Article
- FgCsn12 Is Involved in the Regulation of Ascosporogenesis in the Wheat Scab FungusInternational journal of molecular sciences · 2022Article
- Post-translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review.Environmental microbiology · 2022Review
- Light regulates the degradation of the regulatory protein VE-1 in the fungus Neurospora crassa.BMC biology · 2022Article
- Genetic Networks That Govern Sexual Reproduction in the Pezizomycotina.Microbiology and molecular biology reviews : MMBR · 2021Review
- Essential Role of COP9 Signalosome Subunit 5 (Csn5) in Insect Pathogenicity and Asexual Development ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- The necessity of NEDD8/Rub1 for vitality and its association with mitochondria-derived oxidative stress.Redox biology · 2020Review
- The Third International Symposium on Fungal Stress - ISFUS.Fungal biology · 2020Article
- COP9 Signalosome Interaction with UspA/Usp15 Deubiquitinase Controls VeA-Mediated Fungal Multicellular Development.Biomolecules · 2019Article
- It's All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes.Genes · 2019Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fruit body formation in filamentous fungi is a complex and yet hardly understood process. We show here that protein turnover control is crucial for Aspergillus nidulans development. Deletion of genes encoding COP9 signalosome (CSN) subunits 1, 2, 4, or 5 resulted in identical blocks in fruit body formation. The CSN multiprotein complex controls ubiquitin-dependent protein degradation in eukaryotes. Six CSN subunits interacted in a yeast two-hybrid analysis, and the complete eight-subunit CSN was recruited by a functional tandem affinity purification tag fusion of subunit 5 (CsnE). The tagged CsnE was unable to recruit any CSN subunit in a strain deleted for subunit 1 or subunit 4. Mutations in the JAMM metalloprotease core of CsnE resulted in mutant phenotypes identical to those of csn deletion strains. We propose that a correctly assembled CSN including a functional JAMM links protein turnover to fungal sexual development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.