ArticleProceedings of the National Academy of Sciences of the United States of America2007
Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 102 citations in OpenAlex.
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- Enhancement of resistance by poultry manure and plant hormones (salicylic acid & citric acid) against tobacco mosaic virus.Saudi journal of biological sciences · 2021Article
- Current Status of Chikungunya in India.Frontiers in microbiology · 2021Review
- Natural product sciences: an integrative approach to the innovations of plant natural products.Science China. Life sciences · 2020Review
- Inhibitory Effect of Osthole fromMolecules (Basel, Switzerland) · 2019Article
- An Explorer of Chemical Biology of Plant Natural Products in Southwest China, Xiaojiang Hao.Natural products and bioprospecting · 2018Review
- Anti-TMV Effects of Amaryllidaceae Alkaloids Isolated from the Bulbs of Lycoris radiata and Lycoricidine Derivatives.Natural products and bioprospecting · 2018Article
- A compendium of small molecule direct-acting and host-targeting inhibitors as therapies against alphaviruses.The Journal of antimicrobial chemotherapy · 2017Review
- A terpenoid phytoalexin plays a role in basal defense of Nicotiana benthamiana against Potato virus X.Scientific reports · 2015Article
- Anti-TMV activity of malformin A1, a cyclic penta-peptide produced by an endophytic fungus Aspergillus tubingensis FJBJ11.International journal of molecular sciences · 2015Article
- Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo.Journal of virology · 2014Article
- Bioactive compounds from Vitex leptobotrys.Journal of natural products · 2014Article
- Antiviral perspectives for chikungunya virus.BioMed research international · 2014Review
- Article
- Novel inhibitors of neurotropic alphavirus replication that improve host survival in a mouse model of acute viral encephalitis.Journal of medicinal chemistry · 2012Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants have evolved multiple mechanisms to selectively suppress pathogens by production of secondary metabolites with antimicrobial activities. Therefore, direct selections for antiviral compounds from plants can be used to identify new agents with potent antiviral activity but not toxic to hosts. Here, we provide evidence that a class of compounds, seco-pregnane steroid glaucogenin C and its monosugar-glycoside cynatratoside A of Strobilanthes cusia and three new pantasugar-glycosides of glaucogenin C of Cynanchum paniculatum, are effective and selective inhibitors to alphavirus-like positive-strand RNA viruses including plant-infecting tobacco mosaic virus (TMV) and animal-infecting Sindbis virus (SINV), eastern equine encephalitis virus, and Getah virus, but not to other RNA or DNA viruses, yet they were not toxic to host cells. In vivo administration of the compounds protected BALB/c mice from lethal SINV infection without adverse effects on the mice. Using TMV and SINV as models, studies on the action mechanism revealed that the compounds predominantly suppress the expression of viral subgenomic RNA(s) without affecting the accumulation of viral genomic RNA. Our work suggested that the viral subgenomic RNA could be a new target for the discovery of antiviral drugs, and that seco-pregnane steroid and its four glycosides found in the two medicinal herbs have the potential for further development as antiviral agents against alphavirus-like positive-strand RNA viruses.
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