ArticleThe Journal of cell biology2007
LKB1 and AMPK maintain epithelial cell polarity under energetic stress.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 189 citations in OpenAlex.
- Pooled it
- Circadian autophagy drives iTRF-mediated longevity.Nature · 2021Article
- Insight on Transcriptional Regulation of the Energy Sensing AMPK and Biosynthetic mTOR Pathway Genes.Frontiers in cell and developmental biology · 2020Review
- The follicle epithelium in theeLife · 2019Article
- Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression.Journal of cell science · 2019Article
- Article
- LKB1 deficiency promotes proliferation and invasion of glioblastoma through activation of mTOR and focal adhesion kinase signaling pathways.American journal of cancer research · 2019Article
- Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan.Developmental cell · 2018Article
- Review
- AMP-activated protein kinase: a therapeutic target in intestinal diseases.Open biology · 2017Review
- [Role of interleukin-17 in alveolar fluid clearance in mice with acute lung injury].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
- Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.Trends in pharmacological sciences · 2016Review
- The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.Oncotarget · 2016Article
- LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration.Scientific reports · 2015Article
- Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.Cell metabolism · 2015Article
- Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila.PLoS genetics · 2015Article
- Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Kinome-wide screening of HER2+ breast cancer cells for molecules that mediate cell proliferation or sensitize cells to trastuzumab therapy.Oncogenesis · 2014Article
- Honokiol affects melanoma cell growth by targeting the AMP-activated protein kinase signaling pathway.American journal of surgery · 2014Article
- Epidermal polarity genes in health and disease.Cold Spring Harbor perspectives in medicine · 2014Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2013-10-28Doing the Right Thing · Error in Data · Error in Results and/or Conclusions ·
- Retracted
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5'monophosphate-activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarity and growth control through PAR-1 and AMPK, respectively. However, the genetic analysis of LKB1-AMPK signaling in vertebrates has been complicated by the existence of multiple redundant AMPK subunits. We describe the identification of mutations in the single Drosophila melanogaster AMPK catalytic subunit AMPKalpha. Surprisingly, ampkalpha mutant epithelial cells lose their polarity and overproliferate under energetic stress. LKB1 is required in vivo for AMPK activation, and lkb1 mutations cause similar energetic stress-dependent phenotypes to ampkalpha mutations. Furthermore, lkb1 phenotypes are rescued by a phosphomimetic version of AMPKalpha. Thus, LKB1 signals through AMPK to coordinate epithelial polarity and proliferation with cellular energy status, and this might underlie the tumor suppressor function of LKB1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.