ArticleMolecular and cellular biology2007
The pituitary function of androgen receptor constitutes a glucocorticoid production circuit.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.Biology of sex differences · 2022Article
- Pituitary corticotroph identity and receptor-mediated signaling: a transcriptomics perspective.Current opinion in endocrine and metabolic research · 2022Article
- Adrenal cortex renewal in health and disease.Nature reviews. Endocrinology · 2021Review
- GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.Scientific reports · 2021Article
- The Sexually Dimorphic Adrenal Cortex: Implications for Adrenal Disease.International journal of molecular sciences · 2021Review
- Sexual Dimorphism in Glucocorticoid Stress Response.International journal of molecular sciences · 2021Review
- Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development.Nature communications · 2020Article
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology.EBioMedicine · 2020Article
- Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing.Scientific reports · 2019Article
- Interactive effects of testosterone and cortisol on hippocampal volume and episodic memory in middle-aged men.Psychoneuroendocrinology · 2018Article
- Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse.PloS one · 2015Article
- Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells.Nuclear receptor signaling · 2013Review
- Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.Molecular endocrinology (Baltimore, Md.) · 2012Article
- The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects.Annals of the New York Academy of Sciences · 2012Article
- Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle.Endocrinology and metabolism clinics of North America · 2012Review
- JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation.The Journal of biological chemistry · 2012Article
- Androgen receptors, sex behavior, and aggression.Neuroendocrinology · 2012Review
- Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress.Hormones and behavior · 2011Article
Corrections and comments
- Erratum issued
- Expression of concern
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Androgen receptor (AR) mediates diverse androgen actions, particularly reproductive processes in males and females. AR-mediated androgen signaling is considered to also control metabolic processes; however, the molecular basis remains elusive. In the present study, we explored the molecular mechanism of late-onset obesity in male AR null mutant (ARKO) mice. We determined that the obesity was caused by a hypercorticoid state. The negative feedback system regulating glucocorticoid production was impaired in ARKO mice. Male and female ARKO mice exhibited hypertrophic adrenal glands and glucocorticoid overproduction, presumably due to high levels of adrenal corticotropic hormone. The pituitary glands of the ARKO males had increased expression of proopiomelanocortin and decreased expression of the glucocorticoid receptor (GR). There were no overt structural abnormalities and no alteration in the distribution of cell types in the pituitaries of male ARKO mice. Additionally, there was normal production of the other hormones within the glucocorticoid feedback system in both the pituitary and hypothalamus. In a cell line derived from pituitary glands, GR expression was under the positive control of the activated AR. Thus, this study suggests that the activated AR supports the negative feedback regulation of glucocorticoid production via up-regulation of GR expression in the pituitary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.