ArticleInfection and immunity2007
Leishmania major abrogates gamma interferon-induced gene expression in human macrophages from a global perspective.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Scavenger Receptor BI Deficiency in Mice Is Associated With Plasma Ceramide and Sphingomyelin Accumulation and a Reduced Cholesteryl Ester Fatty Acid Length and Unsaturation Degree.Journal of lipid and atherosclerosis · 2024Article
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- Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology.Frontiers in physiology · 2023Review
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- Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence.The Korean journal of parasitology · 2022Article
- MicroRNAs: master regulators in host-parasitic protist interactions.Open biology · 2022Review
- Transcriptomic Analysis in Human Macrophages Infected with Therapeutic Failure Clinical Isolates ofACS infectious diseases · 2022Article
- Persistent CutaneousMicroorganisms · 2022Article
- Incorporation and influence of Leishmania histone H3 in chromatin.Nucleic acids research · 2019Article
- Model-based Evaluation of Gene Expression Changes in Response toGene regulation and systems biology · 2019Review
- Article
- Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages.Medical microbiology and immunology · 2017Article
- DNA Microarray Detection of 18 Important Human Blood Protozoan Species.PLoS neglected tropical diseases · 2016Article
- Identification of Synthetic and Natural Host Defense Peptides with Leishmanicidal Activity.Antimicrobial agents and chemotherapy · 2016Article
- Changes in Macrophage Gene Expression Associated with Leishmania (Viannia) braziliensis Infection.PloS one · 2015Article
- Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages.PLoS pathogens · 2014Article
- Identifying vaccine targets for anti-leishmanial vaccine development.Expert review of vaccines · 2014Review
- A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice.PLoS neglected tropical diseases · 2014Article
- Signaling networks in Leishmania macrophages deciphered through integrated systems biology: a mathematical modeling approach.Systems and synthetic biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with Leishmania major triggers several pathways in the host cell that are crucial to initial infection as well as those that are used by Leishmania to enhance its replication and virulence. To identify the molecular events of the host cell in response to Leishmania, the global gene expression of the human monocytic cell line THP-1 either infected with Leishmania major in the presence and absence of gamma interferon (IFN-gamma) or in the presence of IFN-gamma alone was analyzed using high-density human oligonucleotide microarrays, followed by statistical analysis. The persistence of the parasite despite an extensive response to IFN-gamma, added 24 h after infection with L. major, suggests that L. major can survive in an IFN-gamma-enriched environment in vitro. Results demonstrate that L. major counteracts the IFN-gamma response in macrophages on a large scale. Expression of genes involved in the innate immune response, cell adhesion, proteasomal degradation, Toll-like receptor expression, a variety of signaling molecules, and matrix metalloproteinases was significantly modulated.
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