ArticleArthritis and rheumatism2007
Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases.
Article in Arthritis and rheumatism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Prevalence and prognostic value of activated protein C resistance and anti-protein C antibodies in patients with aPLs: an APS ACTION Registry study.Rheumatology (Oxford, England) · 2026Article
- Hemostasis System and Plasminogen Activity in Retrochorial Hematoma in the First Trimester of Pregnancy.Biomedicines · 2022Article
- Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production.Arthritis research & therapy · 2021Article
- The Weight of IgA Anti-β2glycoprotein I in the Antiphospholipid Syndrome Pathogenesis: Closing the Gap of Seronegative Antiphospholipid Syndrome.International journal of molecular sciences · 2020Review
- Lytic Susceptibility, Structure, and Mechanical Properties of Fibrin in Systemic Lupus Erythematosus.Frontiers in immunology · 2019Article
- Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.Scientific reports · 2017Article
- Anti-factor Xa antibodies in patients with antiphospholipid syndrome and their effects upon coagulation assays.Arthritis research & therapy · 2015Article
- Insights into the pathophysiology of the antiphospholipid syndrome provided by atomic force microscopy.Micron (Oxford, England : 1993) · 2012Review
- Hydroxychloroquine reduces binding of antiphospholipid antibodies to syncytiotrophoblasts and restores annexin A5 expression.American journal of obstetrics and gynecology · 2011Article
- Interactions of human monoclonal and polyclonal antiphospholipid antibodies with serine proteases involved in hemostasis.Arthritis and rheumatism · 2011Article
- Article
- Pathophysiological mechanisms in antiphospholipid syndrome.International journal of clinical rheumatology · 2011Article
- Antiphospholipid Syndrome during pregnancy: the state of the art.Journal of prenatal medicine · 2011Article
- Anti-plasminogen antibodies compromise fibrinolysis and associate with renal histology in ANCA-associated vasculitis.Journal of the American Society of Nephrology : JASN · 2010Article
- Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines.The Journal of experimental medicine · 2010Article
- In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1.Journal of virology · 2010Article
- Antibodies to serine proteases in the antiphospholipid syndrome.Current rheumatology reports · 2010Review
- Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo.Blood · 2009Article
- Plasmin immunization preferentially induces potentially prothrombotic IgG anticardiolipin antibodies in MRL/MpJ mice.Arthritis and rheumatism · 2009Article
- Mechanisms of antiphospholipid-induced thrombosis: effects on the protein C system.Current rheumatology reports · 2009Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that some antiphospholipid antibodies (aPL) in patients with the antiphospholipid syndrome (APS) recognize a conformational epitope shared by beta2-glycoprotein I (beta2GPI; the major autoantigen for the antiphospholipid antibodies) and the homologous catalytic domains of several serine proteases (such as thrombin, activated protein C [APC], and plasmin) involved in hemostasis.
methodsWe generated 4 new IgG monoclonal aPL (2 screened against beta2GPI, 1 against thrombin, and 1 against protein C) from 2 APS patients. The monoclonal antibodies (mAb) were analyzed for binding to beta2GPI, thrombin, APC, and plasmin, as well as for anticardiolipin antibody (aCL) activity. To demonstrate a shared epitope between beta2GPI and a serine protease, 1 mAb was studied by cross-inhibition analysis.
resultsBoth of the IgG anti-beta2GPI mAb bound to thrombin, APC, and plasmin. On the other hand, the 1 anti-thrombin mAb and the 1 anti-protein C mAb also bound to beta2GPI. Moreover, the binding of 1 cross-reactive mAb to beta2GPI was inhibited by alpha-thrombin (which contains only the catalytic domain of thrombin). All 4 mAb displayed aCL activity.
conclusionTaken together with the findings that some aCL bind to several serine proteases that participate in hemostasis and share homologous catalytic domains, these data demonstrate that some aCL in APS patients recognize one or more conformational epitopes shared by beta2GPI and the catalytic domains of disease-relevant serine proteases.
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