Evidence map›Paper›PMID 17468954›Full record

ReviewNeurochemical research2007

Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms.

Daniela Berg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. MR imaging differentiation of FeNeuroradiology · 2017
    Article
  8. Article
  9. Bioavailable Trace Metals in Neurological Diseases.Current treatment options in neurology · 2016
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Drug targets from genetics: α-synuclein.CNS & neurological disorders drug targets · 2011
    Review
  16. Article
  17. Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: no.Journal of neural transmission (Vienna, Austria : 1996) · 2011
    Article
  18. Iron-dependent functions of mitochondria--relation to neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2011
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniela BergHertie Institute of Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tubingen, Germany. daniela.berg@uni-tuebingen.de
Hertie Institute for Clinical Brain Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of investigations have provided evidence for a central role of iron in the pathogenesis of Parkinson's disease (PD). Recently it could be demonstrated that iron related changes of the substantia nigra may be one important factor contributing to the hyperechogenicity typicall visualized by transcranial sonography in idiopathic PD. Moreover, also patients with monogenetically caused PD show this hyperechogenicity, although to a lesser extent. According to numerous findings and experiments it seems plausible that iron also contributes to the pathophysiological cascades in the monogenetic forms of PD. Therefore, it is not only essential to acknowledge the pivotal role of iron for PD, but also to enhance the effort in finding therapeutic strategies to prevent the impact of iron on neurodegenerative processes. Moreover, early detection of subjects at risk is essential for the application of therapeutic strategies at a stage at which neuroprotection is still possible.

Indexed as

Brain ChemistryHumansIronParkinson DiseaseUbiquitin-Protein LigasesUltrasonographyIronparkin proteinUbiquitin-Protein Ligases

Identifiers

PMID17468954
OpenAlexW1987794323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.