ArticleBiophysical journal2007
Force versus axial deflection of pipette-aspirated closed membranes.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Biomembrane force probe (BFP): Design, advancements, and recent applications to live-cell mechanobiology.Exploration (Beijing, China) · 2023Review
- Benchmarks of Biomembrane Force Probe Spring Constant Models.Biophysical journal · 2017Article
- Micropipette force probe to quantify single-cell force generation: application to T-cell activation.Molecular biology of the cell · 2017Article
- Curvature-Driven Migration of Colloids on Tense Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- Effect of loading conditions on the dissociation behaviour of catch bond clusters.Journal of the Royal Society, Interface · 2012Article
- An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes).Cellular and molecular bioengineering · 2011Article
- Force generation upon T cell receptor engagement.PloS one · 2011Article
- Biomembrane force probe investigation of RNA dissociation.European biophysics journal : EBJ · 2011Article
- Single-cell adhesion tests against functionalized microspheres arrayed on AFM cantilevers confirm heterophilic E- and N-cadherin binding.Biophysical journal · 2010Article
- Squeezing and detachment of living cells.Biophysical journal · 2010Article
- Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Adhesion and membrane tension of single vesicles and living cells using a micropipette-based technique.The European physical journal. E, Soft matter · 2009Article
- Versatile horizontal force probe for mechanical tests on pipette-held cells, particles, and membrane capsules.Biophysical journal · 2009Article
- How accurate are ultrasensitive biophysical force probes?Biophysical journal · 2007Article
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2 authors.
Funding
Abstract
The axial deformation of a pipette-pressurized fluid membrane bag produces minuscule yet well-defined, reproducible forces. The stiffness of this ultrasensitive force transducer is tunable and largely independent of the constitutive membrane behavior. Based on a rigorous variational treatment, we present both numerical as well as approximate analytical solutions for the force-deflection relation of this unique biophysical force probe. Our numerical results predict a measurably nonlinear force-deflection behavior at moderate-to-large deformations, which we confirm experimentally using red blood cells. Furthermore, considering nearly spherical membrane shapes and enforcing proper boundary conditions, we derive an analytical solution valid at small deformations. In this linear regime the pressurized membrane bag behaves like a Hookean spring, with a spring constant that is significantly larger than previously published for the biomembrane force probe.
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