ReviewTrends in neurosciences2007
Wnts: up-and-coming at the synapse.
Review in Trends in neurosciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 122 citations in OpenAlex.
- Emerging Epigenetic Therapeutics and Diagnostics for Autism Spectrum Disorder.Current issues in molecular biology · 2025Review
- Tissue-specific knockout in the Drosophila neuromuscular system reveals ESCRT's role in formation of synapse-derived extracellular vesicles.PLoS genetics · 2024Article
- Identification of a Novel Wnt Antagonist Based Therapeutic and Diagnostic Target for Alzheimer's Disease Using a Stem Cell-Derived Model.Bioengineering (Basel, Switzerland) · 2023Article
- Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review.Open biology · 2022Review
- WNT Signaling Is a Key Player in Alzheimer's Disease.Handbook of experimental pharmacology · 2021Article
- Wnt/β-Catenin-Dependent Transcription in Autism Spectrum Disorders.Frontiers in molecular neuroscience · 2021Review
- Wnt/beta-Catenin Signaling Contributes to Vincristine-Induced Neuropathic Pain.Physiological research · 2020Article
- Synapse development and maturation at the drosophila neuromuscular junction.Neural development · 2020Review
- dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.Cytoskeleton (Hoboken, N.J.) · 2020Article
- Article
- WNT Signaling in Disease.Cells · 2019Review
- Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling.Molecular neurobiology · 2019Article
- Wnt proteins as modulators of synaptic plasticity.Current opinion in neurobiology · 2018Review
- Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease.Neural regeneration research · 2018Review
- Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8.Scientific reports · 2017Article
- Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Superfamily Protein RIG-3 inGenetics · 2017Article
- Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry.Molecular neuropsychiatry · 2017Review
- Article
- Early postnatal exposure to lithium in vitro induces changes in AMPAR mEPSCs and vesicular recycling at hippocampal glutamatergic synapses.Journal of biosciences · 2015Article
- Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein.PloS one · 2015Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic development, function and plasticity are highly regulated processes requiring a precise coordination of pre- and postsynaptic events. Recent studies have begun to highlight Wingless-Int (Wnt) signaling as a key player in synapse differentiation and function. Emerging roles of Wnts include the differentiation of synaptic specializations, microtubule dynamics, architecture of synaptic protein organization, modulation of synaptic efficacy and regulation of gene expression. These processes are driven by a variety of Wnt transduction pathways. Combined with a myriad of Wnts and Frizzled receptor family members, these pathways highlight the versatility of Wnt signaling and the potential for combinatorial use of these pathways in different aspects of synapse development and function. The identification of neurons secreting Wnt and those containing molecular components downstream of Frizzled receptors indicates that Wnts can function both as anterograde and retrograde signals. These studies open new avenues for understanding how embryonic morphogens are utilized during the development and function of synaptic networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.