ArticleBrain pathology (Zurich, Switzerland)2007
Congenital glioblastoma: a clinicopathologic and genetic analysis.
Article in Brain pathology (Zurich, Switzerland), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01574092 (Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas
Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
- A Rare Case of Giant Congenital/Infant-type Hemispheric Glioma Harboring Concomitant ALK and EGFR Alteration.NMC case report journal · 2025Article
- Genomic and epigenomic re-categorization of congenital glioblastoma and desmoplastic infantile ganglioglioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Article
- Distinct survival and clinical profile of infantile glioblastoma: insights from a national database.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Imaging of fetal brain tumors.Pediatric radiology · 2020Review
- Infantile/Congenital High-Grade Gliomas: Molecular Features and Therapeutic Perspectives.Diagnostics (Basel, Switzerland) · 2020Review
- Targetable molecular alterations in congenital glioblastoma.Journal of neuro-oncology · 2020Article
- Perinatal (fetal and neonatal) astrocytoma: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.Italian journal of pediatrics · 2016Review
- Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.Brain pathology (Zurich, Switzerland) · 2015Article
- Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells.Molecular & cellular proteomics : MCP · 2014Article
- Paediatric spinal glioblastoma: case report and review of therapeutic strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Clinical and molecular characteristics of congenital glioblastoma.Neuro-oncology · 2012Article
- Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.Molecular cancer research : MCR · 2012Article
- Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q.Neuro-oncology · 2010Article
- Pediatric glioblastomas: a histopathological and molecular genetic study.Neuro-oncology · 2009Article
- Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas.European journal of pediatrics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Congenital central nervous system (CNS) tumors are uncommon, accounting for 1% of all childhood brain tumors. They present clinically either at birth or within the first 3 months. Glioblastoma (GBM) only rarely occurs congenitally and has not been fully characterized. We examined clinicopathologic features and genetic alterations of six congenital GBMs. Tumors were seen by neuroimaging as large, complex cerebral hemispheric masses. All showed classic GBM histopathology, including diffuse infiltration, dense cellularity, GFAP-positivity, high mitotic activity, endothelial proliferation and pseudopalisading necrosis. Neurosurgical procedures and adjuvant therapies varied. Survivals ranged from 4 days to 7.5 years; two of the three long-term survivors received chemotherapy, whereas the three short-term survivors did not. Paraffin-embedded tissue sections were used for FISH analysis of EGFR, chromosomes 9p21 (p16/CDKN2A) and 10q ( PTEN/DMBT1); sequencing of PTEN and TP53; and immunohistochemistry for EGFR and p53. We uncovered 10q deletions in two cases. No EGFR amplifications, 9p21 deletions, or mutations of TP53 or PTEN were noted; however, nuclear p53 immunoreactivity was strong in 5/6 cases. Tumors were either minimally immunoreactive (n = 3) or negative (n = 3) for EGFR. We conclude that congenital GBMs show highly variable survivals. They are genetically distinct from their adult counterparts and show a low frequency of known genetic alterations. Nonetheless, the strong nuclear expression of p53 in these and other pediatric GBMs could indicate that p53 dysregulation is important to tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.