ArticlePharmacogenomics2007
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing.
Article in Pharmacogenomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Article
- Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?The pharmacogenomics journal · 2024Review
- Bridging the Gaps in Personalized Medicine Value Assessment: A Review of the Need for Outcome Metrics across Stakeholders and Scientific Disciplines.Public health genomics · 2019Review
- DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.Oncotarget · 2016Review
- Measures of exposure impact genetic association studies: an example in vitamin K levels and VKORC1.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2015Article
- Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records.Pharmacogenomics · 2013Article
- Practical Consideration of Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped Rate.Statistics and its interface · 2011Article
- VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.PloS one · 2010Article
- CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic dosing.Pharmacogenomics · 2009Article
- A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.Blood · 2008Article
- Article
- Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Genotype-phenotype studies in pharmacogenomics promise to identify the genetic factors that contribute substantially to variation in individual drug response. While most genetic association studies have failed to deliver this promise, several recent examples serve as a reminder that these associations do exist and can be identified when investigated using well-designed studies. Here, we describe the path taken to identify the association between common vitamin K epoxide reductase complex subunit 1 genetic variation and warfarin dosing in patients. We also describe the key elements that led the way, such as definition of the phenotype, confirmation of a genetic component, determination of biological plausibility and selection of genetic polymorphisms. We also describe several avenues that are yet to be explored for the specific vitamin K epoxide reductase complex subunit 1 warfarin example that can also be generalized as future directions for many genetic association studies in pharmacogenomics. These future avenues will be best explored using diverse approaches encompassing clinical, statistical and genomic methods currently being developed for genotype-phenotype studies in human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.