ArticlePLoS computational biology2007
Patterns of mesenchymal condensation in a multiscale, discrete stochastic model.
Article in PLoS computational biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Contributions of cell behavior to geometric order in embryonic cartilage.PLoS computational biology · 2023Article
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- Combined computational modeling and experimental analysis integrating chemical and mechanical signals suggests possible mechanism of shoot meristem maintenance.PLoS computational biology · 2022Article
- Mechanical Regulation of Limb Bud Formation.Cells · 2022Review
- Interplay of mesoscale physics and agent-like behaviors in the parallel evolution of aggregative multicellularity.EvoDevo · 2020Review
- Article
- From Skeletal Development to Tissue Engineering: Lessons from the Micromass Assay.Tissue engineering. Part B, Reviews · 2015Review
- Introduction of a Framework for Dynamic Knowledge Representation of the Control Structure of Transplant Immunology: Employing the Power of Abstraction with a Solid Organ Transplant Agent-Based Model.Frontiers in immunology · 2015Article
- Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.PloS one · 2015Article
- Agent-based model of fecal microbial transplant effect on bile acid metabolism on suppressing Clostridium difficile infection: an example of agent-based modeling of intestinal bacterial infection.Journal of pharmacokinetics and pharmacodynamics · 2014Article
- An integrated computational model of the bone microenvironment in bone-metastatic prostate cancer.Cancer research · 2014Article
- Tunable and dynamic soft materials for three-dimensional cell culture.Soft matter · 2013Article
- Time-dependent processes in stem cell-based tissue engineering of articular cartilage.Stem cell reviews and reports · 2012Article
- Digit patterning during limb development as a result of the BMP-receptor interaction.Scientific reports · 2012Article
- Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.Developmental cell · 2011Article
- Techniques for analysing pattern formation in populations of stem cells and their progeny.BMC bioinformatics · 2011Article
- Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms.BMC systems biology · 2010Article
- Article
- Individual fates of mesenchymal stem cells in vitro.BMC systems biology · 2010Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Cells of the embryonic vertebrate limb in high-density culture undergo chondrogenic pattern formation, which results in the production of regularly spaced "islands" of cartilage similar to the cartilage primordia of the developing limb skeleton. The first step in this process, in vitro and in vivo, is the generation of "cell condensations," in which the precartilage cells become more tightly packed at the sites at which cartilage will form. In this paper we describe a discrete, stochastic model for the behavior of limb bud precartilage mesenchymal cells in vitro. The model uses a biologically motivated reaction-diffusion process and cell-matrix adhesion (haptotaxis) as the bases of chondrogenic pattern formation, whereby the biochemically distinct condensing cells, as well as the size, number, and arrangement of the multicellular condensations, are generated in a self-organizing fashion. Improving on an earlier lattice-gas representation of the same process, it is multiscale (i.e., cell and molecular dynamics occur on distinct scales), and the cells are represented as spatially extended objects that can change their shape. The authors calibrate the model using experimental data and study sensitivity to changes in key parameters. The simulations have disclosed two distinct dynamic regimes for pattern self-organization involving transient or stationary inductive patterns of morphogens. The authors discuss these modes of pattern formation in relation to available experimental evidence for the in vitro system, as well as their implications for understanding limb skeletal patterning during embryonic development.
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