ReviewAmerican journal of human genetics1991
A random walk method for computing genetic location scores.
Review in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- A fast linkage method for population GWAS cohorts with related individuals.Genetic epidemiology · 2023Article
- Analysis of pedigree data in populations with multiple ancestries: Strategies for dealing with admixture in Caribbean Hispanic families from the ADSP.Genetic epidemiology · 2018Article
- PBAP: a pipeline for file processing and quality control of pedigree data with dense genetic markers.Bioinformatics (Oxford, England) · 2015Article
- Mining disease genes using integrated protein-protein interaction and gene-gene co-regulation information.FEBS open bio · 2015Article
- Pedigree-Free Descent-Based Gene Mapping from Population Samples.Human heredity · 2015Article
- Efficient identification of equivalences in dynamic graphs and pedigree structures.Journal of computational biology : a journal of computational molecular cell biology · 2013Article
- Review
- Computationally efficient multipoint linkage analysis on extended pedigrees for trait models with two contributing major Loci.Genetic epidemiology · 2012Article
- Improving pedigree-based linkage analysis by estimating coancestry among families.Statistical applications in genetics and molecular biology · 2012Article
- The structure of genetic linkage data: from LIPED to 1M SNPs.Human heredity · 2011Article
- Estimation and visualization of identity-by-descent within pedigrees simplifies interpretation of complex trait analysis.Human heredity · 2011Article
- Reconstructing CNV genotypes using segregation analysis: combining pedigree information with CNV assay.Genetics, selection, evolution : GSE · 2010Article
- Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates.Human molecular genetics · 2009Article
- Multilocus lod scores in large pedigrees: combination of exact and approximate calculations.Human heredity · 2008Article
- Multipoint linkage analysis with many multiallelic or dense diallelic markers: Markov chain-Monte Carlo provides practical approaches for genome scans on general pedigrees.American journal of human genetics · 2006Article
- Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia.Human genetics · 2005Article
- Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.American journal of human genetics · 2004Article
- Detection and integration of genotyping errors in statistical genetics.American journal of human genetics · 2002Article
- An approximate model of polygenic inheritance.Genetics · 1997Article
- An approximation to the likelihood for a pedigree with loops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Calculation of location scores is one of the most computationally intensive tasks in modern genetics. Since these scores are crucial in placing disease loci on marker maps, there is ample incentive to pursue such calculations with large numbers of markers. However, in contrast to the simple, standardized pedigrees used in making marker maps, disease pedigrees are often graphically complex and sparsely phenotyped. These complications can present insuperable barriers to exact likelihood calculations with more than a few markers simultaneously. To overcome these barriers we introduce in the present paper a random walk method for computing approximate location scores with large numbers of biallelic markers. Sufficient mathematical theory is developed to explain the method. Feasibility is checked by small-scale simulations for two applications permitting exact calculation of location scores.
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1746559PMC1686461What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.