ArticleAmerican journal of human genetics1991
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- ATM haplotypes and associated mutations in Iranian patients with ataxia-telangiectasia: recurring homozygosity without a founder haplotype.Human genetics · 2005Article
- Severe microcephaly with normal intellectual development: the Nijmegen breakage syndrome.Archives of disease in childhood · 1995Article
- Mapping eight new polymorphisms in 11q13 in the vicinity of multiple endocrine neoplasia type 1: identification of a new distal recombinant.Human genetics · 1995Article
- Molecular genetics of familial breast-ovarian cancer.Journal of clinical pathology · 1995Review
- Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.American journal of human genetics · 1995Article
- Sublocalization of an ataxia-telangiectasia gene distal to D11S384 by ancestral haplotyping in Costa Rican families.American journal of human genetics · 1995Article
- A high-density microsatellite map of the ataxia-telangiectasia locus.Human genetics · 1995Article
- Studies on phenotypic complementation of ataxia-telangiectasia cells by chromosome transfer.American journal of human genetics · 1995Article
- New localization of NCAM, proximal to DRD2 at chromosome 11q23.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Ordering markers in the region of the ataxia-telangiectasia gene (11q22-q23) by fluorescence in situ hybridization (FISH) to interphase nuclei.Human genetics · 1994Article
- Absence of linkage to the ataxia telangiectasia locus in familial breast cancer.Human genetics · 1993Article
- Ordering genes: controlling the decision-error probabilities.American journal of human genetics · 1993Article
- Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer.British journal of cancer · 1993Article
- Cloning of a candidate gene for ataxia-telangiectasia group D.American journal of human genetics · 1992Article
- Ataxia-telangiectasia: linkage evidence for genetic heterogeneity.American journal of human genetics · 1992Article
- A random walk method for computing genetic location scores.American journal of human genetics · 1991Review
Corrections and comments
- Commented on by
Authors and funding
20 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 10(8) times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5.2 cM (sex-averaged and conservatively based on 3 lod scores from the maximum-location score) or 2.8 cM (male specific, based on a 2.72:1 interval-specific female-to-male distance ratio.
Indexed as
Identifiers
1746555PMC1686455W2067683904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.