ArticleWorld journal of gastroenterology2007
Surgical anatomy of innervation of the gallbladder in humans and Suncus murinus with special reference to morphological understanding of gallstone formation after gastrectomy.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Analgesic benefits of pre-operative versus postoperative transversus abdominis plane block for laparoscopic cholecystectomy: a frequentist network meta-analysis of randomized controlled trials.BMC anesthesiology · 2023Pooled it
- Prophylactic cholecystectomy: A valuable treatment strategy for cholecystolithiasis after gastric cancer surgery.Frontiers in oncology · 2022Pooled it
- Preemptive visceral analgesic effect of thoracic paravertebral block on postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, assessor-blind study.Korean journal of anesthesiology · 2023Trial
- The Cholegas Study: safety of prophylactic cholecystectomy during gastrectomy for cancer: preliminary results of a multicentric randomized clinical trial.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Trial
- Gallbladder torsion in multimorbid older adults: a structured narrative review and case report.BMC geriatrics · 2026Review
- Lumbar Hypobaric Spinal Anesthesia Combined With Intermediate Cervical Plexus Block for Upper Abdominal Laparoscopy: A Case Report.A&A practice · 2026Article
- Ultrasound Improves Gallbladder Contraction Function: A Non-Invasive Experimental Validation Using Small Animals.Bioengineering (Basel, Switzerland) · 2025Article
- A case of acute acalculous cholecystitis after pulmonary vein isolation-novel phenotype of perioesophageal vagal nerve injury: a case report.European heart journal. Case reports · 2025Article
- Evaluation of the necessity of simultaneous cholecystectomy in patients undergoing liver hydatid cyst surgery.Surgery open science · 2025Article
- Gallstone formation and subsequent cholecystectomy after oncological gastric and esophageal resection.Langenbeck's archives of surgery · 2024Article
- Exploring ideal operative time for best outcomes in gastric cancer surgery: A multi-institutional study based on KLASS-07 database.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023Article
- Heart rhythm irregularities during laparoscopy: Description of a novel technique to manage severe intra-operative bradycardia - A case report.International journal of surgery case reports · 2023Article
- Article
- Short-term outcomes after simultaneous gastrectomy plus cholecystectomy in gastric cancer: A pooling up analysis.Open medicine (Warsaw, Poland) · 2023Article
- Fecal microbiota transplantation fromFrontiers in microbiology · 2023Article
- Acute cholecystitis secondary toBMJ case reports · 2022Article
- Clinical Characteristics of Symptomatic Cholecystitis in Post-Gastrectomy Patients: 11 Years of Experience in a Single Center.Medicina (Kaunas, Lithuania) · 2022Review
- Schwann Cells in Digestive System Disorders.Cells · 2022Review
- Important risk factors for gallstones after laparoscopic gastrectomy: a retrospective study.BMC surgery · 2022Article
- The Effect of Minimally Invasive Gastrectomy for Gastric Cancer on Postoperative Gallstone Formation.World journal of surgery · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo clarify the innervation of human gallbladder, with special reference to morphological understanding of gallstone formation after gastrectomy.
methodsThe liver, gallbladder and surrounding structures were immersed in a 10 mg/L solution of alizarin red S in ethanol to stain the peripheral nerves in cadavers (n=10). Innervation in the areas was completely dissected under a binocular microscope. Similarly, innervation in the same areas of 10 Suncus murinus (S. murinus) was examined employing whole mount immunohistochemistry.
resultsInnervation of the gallbladder occurred predominantly through two routes. One was from the anterior hepatic plexus, the innervation occurred along the cystic arteries and duct. Invariably this route passed through the hepatoduodenal ligament. The other route was from the posterior hepatic plexus, the innervation occurred along the cystic duct ventrally. This route also passed through the hepatoduodenal ligament dorsally. Similar results were obtained in S. murinus.
conclusionThe route from the anterior hepatic plexus via the cystic artery and/or duct is crucial for preserving gallbladder innervation. Lymph node dissection specifically in the hepatoduodenal ligament may affect the incidence of gallstones after gastrectomy. Furthermore, the route from the posterior hepatic plexus via the common bile duct and the cystic duct to the gallbladder should not be disregarded. Preservation of the plexus may attenuate the incidence of gallstone formation after gastrectomy.
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