ArticleEpigenetics
Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2.
Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome.The FEBS journal · 2026Article
- Class 1 histone deacetylases differentially modulate memory and synaptic genes in a spatial and temporal manner in aged and APP/PS1 mice.Brain research · 2024Article
- Role of primary aging hallmarks in Alzheimer´s disease.Theranostics · 2023Review
- MeCP2: The Genetic Driver of Rett Syndrome Epigenetics.Frontiers in genetics · 2021Review
- A 2x folic acid treatment affects epigenetics and dendritic spine densities in SHSY5Y cells.Biochemistry and biophysics reports · 2019Article
- NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.Schizophrenia research · 2016Article
- Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease.Neurobiology of aging · 2015Article
- Specificity, propagation, and memory of pericentric heterochromatin.Molecular systems biology · 2014Article
- Rett syndrome and MeCP2.Neuromolecular medicine · 2014Review
- MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation.Neurobiology of disease · 2011Article
- Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.Neuropharmacology · 2011Article
- Plasticity of the stress response early in life: mechanisms and significance.Developmental psychobiology · 2010Review
- Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13.Neurobiology of disease · 2010Review
- Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar size.Human molecular genetics · 2009Article
- High throughput characterization of combinatorial histone codes.Molecular & cellular proteomics : MCP · 2009Article
- Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology.Nature neuroscience · 2009Article
- Epigenetic regulation of mammalian stem cells.Stem cells and development · 2008Review
- MECP2 promoter methylation and X chromosome inactivation in autism.Autism research : official journal of the International Society for Autism Research · 2008Article
- MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness.Mammalian genome : official journal of the International Mammalian Genome SocietyReview
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Mutations within the gene encoding methyl CpG binding protein 2 (MECP2) cause the autism-spectrum neurodevelopmental disorder Rett Syndrome (RTT). MECP2 recruits histone deacetylase to methylated DNA and acts as a long-range regulator of methylated genes. Despite ubiquitous MECP2 expression, the phenotype of RTT and the Mecp2-deficient mouse is largely restricted to the postnatal brain. Since Mecp2-deficient mice have a defect in neuronal maturation, we sought to understand how MECP2/Mecp2 mutations globally affect histone modifications during postnatal brain development by an immunofluorescence approach. Using an antibody specific to acetylated histone H3 lysine 9 (H3K9ac), a bright punctate nuclear staining pattern was observed as MECP2 expression increased in early postnatal neuronal nuclei. As neurons matured in juvenile and adult brain samples, the intensity of H3K9ac staining was reduced. Mecp2-deficient mouse and RTT cerebral neurons lacked this developmental reduction in H3K9ac staining compared to age-matched controls, resulting in a significant increase in neuronal nuclei with bright H3K9ac punctate staining. In contrast, trimethylated histone H3 lysine 9 (H3K9me3) localized to heterochromatin independent of MeCP2, but showed significantly reduced levels in Mecp2 deficient mouse and RTT brain. Autism brain with reduced MECP2 expression displayed similar histone H3 alterations as RTT brain. These observations suggest that MeCP2 regulates global histone modifications during a critical postnatal stage of neuronal maturation. These results have implications for understanding the molecular pathogenesis of RTT and autism in which MECP2 mutation or deficiency corresponds with arrested neurodevelopment.
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