Evidence map›Paper›PMID 17463411›Full record

ArticleAmerican journal of respiratory and critical care medicine2007

The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults.

Kai-Jen Chuang, Chang-Chuan Chan, Ta-Chen Su, Chung-Te Lee, Chin-Sheng Tang

Abstract read
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In one paragraph

Article in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 9 pooled it
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

291 citing papers in PubMed, 9 syntheses or guidelines pooled it, 688 citations in OpenAlex.

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  8. Welding Fume Exposure and Epigenetic Alterations: A Systematic Review.International journal of environmental research and public health · 2019
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231 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Kai-Jen ChuangInstitute of Occupational Medicine and Industrial Hygiene, College of Public Health, Taiwan.
Chang-Chuan Chan
Ta-Chen Su
Chung-Te Lee
Chin-Sheng Tang
Institute of Medical Microbiology and Hygiene · DEFu Jen Catholic University · TWNational Central University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe biological mechanisms linking air pollution to cardiovascular events still remain largely unclear.

objectivesTo investigate whether biological mechanisms linking air pollution to cardiovascular events occurred concurrently in human subjects exposed to urban air pollutants.

methodsWe recruited a panel of 76 young, healthy students from a university in Taipei. Between April and June of 2004 or 2005, three measurements were made in each participant of high-sensitivity C-reactive protein (hs-CRP), 8-hydroxy-2'-deoxyguanosine (8-OHdG), plasminogen activator fibrinogen inhibitor-1 (PAI-1), tissue-type plasminogen activator (tPA) in plasma, and heart rate variability (HRV). Gaseous air pollutants were measured at one air-monitoring station inside their campus, and particulate air pollutants were measured at one particulate matter supersite monitoring station 1 km from their campus. We used linear mixed-effects models to associate biological endpoints with individual air pollutants averaged over 1- to 3-day periods before measurements were performed. MEASUREMENTS AND MAIN

resultsWe found that increases in hs-CRP, 8-OHdG, fibrinogen, and PAI-1, and decreases in HRV indices were associated with increases in levels of particles with aerodynamic diameters less than 10 microm and 2.5 microm, sulfate, nitrate, and ozone (O(3)) in single-pollutant models. The increase in 8-OHdG, fibrinogen, and PAI-1, and the reduction in HRV remained significantly associated with 3-day averaged sulfate and O(3) levels in two-pollutant models. There were moderate correlations (r = -0.3) between blood markers of hs-CRP, fibrinogen, PAI-1, and HRV indices.

conclusionsUrban air pollution is associated with inflammation, oxidative stress, blood coagulation and autonomic dysfunction simultaneously in healthy young humans, with sulfate and O(3) as two major traffic-related pollutants contributing to such effects.

Indexed as

Urban Health8-Hydroxy-2'-DeoxyguanosineAdolescentAdultAir PollutantsAir PollutionBiomarkersBlood CoagulationC-Reactive ProteinDeoxyguanosineEnvironmental MonitoringFemaleFibrinogenHeart RateHumansInflammation8-Hydroxy-2'-DeoxyguanosineAir PollutantsBiomarkersC-Reactive ProteinDeoxyguanosineFibrinogenPlasminogen Activator Inhibitor 1Tissue Plasminogen Activator

Identifiers

PMID17463411
OpenAlexW2148432391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.