ArticleThe Journal of physiology2007
Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 82 citations in OpenAlex.
- Impaired modulation of postjunctional αThe Journal of physiology · 2018Trial
- Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.American journal of physiology. Heart and circulatory physiology · 2009Trial
- Age-related differences in the sympathetic-hemodynamic balance in men.Hypertension (Dallas, Tex. : 1979) · 2009Trial
- Impaired exercise hemodynamic responses in patients with HFpEF without a sympathetic vasoconstrictor reserve.Autonomic neuroscience : basic & clinical · 2025Article
- Impaired cardiopulmonary baroreflex function and altered cardiovascular responses to hypovolemia in patients with heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- The potential therapeutic benefits of low frequency haemodynamic oscillations.The Journal of physiology · 2022Article
- Review
- Sympathetic neurohemodynamic transduction is attenuated in older males independent of aerobic fitness.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Forearm vascular resistance responses to the Valsalva maneuver in healthy young and older adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Article
- Non-invasive detection of a femoral-to-radial arterial pressure gradient in intensive care patients with vasoactive agents.Journal of intensive care · 2021Article
- Blunted sympathetic neurovascular transduction is associated to the severity of obstructive sleep apnea.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Spleen Perfusion as an Index of Gender Impact on Sympathetic Nervous System Response to Exercise.Frontiers in physiology · 2021Article
- Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Sex Differences in the Sympathetic Neural Recruitment and Hemodynamic Response to Head-Up Tilt in Older Hypertensives.Hypertension (Dallas, Tex. : 1979) · 2020Article
- α-Adrenergic receptor regulation of skeletal muscle blood flow during exercise in heart failure patients with reduced ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Sympathetic nervous system activation reduces contraction-induced rapid vasodilation in the leg of humans independent of age.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Effects of aging and exercise training on the dynamics of vasoconstriction in skeletal muscle resistance vessels.European journal of applied physiology · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Muscle sympathetic vasoconstrictor nerve activity increases with advancing age, but does not result in elevated forearm vasoconstrictor tone because of a selective reduction in alpha1-adrenoceptor responsiveness. In contrast, the leg circulation of older adults is under greater tonic sympathetic vasoconstriction, but it is unclear whether alpha-adrenoceptor responsiveness is altered with age. In the present study, we tested the hypothesis that postjunctional alpha-adrenergic vasoconstrictor responsiveness is reduced in the leg circulation with age. We measured femoral blood flow (Doppler ultrasound) and calculated the femoral vascular conductance (FVC) responses to alpha-adrenoceptor stimulation during local blockade of beta-adrenoceptors in 12 young (24 +/- 1 year) and seven healthy older men (62 +/- 2 year). Whole-leg vasoconstrictor responses to local intrafemoral artery infusions of tyramine (evokes noradrenaline (NA) release), phenylephrine (alpha1-agonist) and dexmedetomidine (alpha2-agonist) were assessed. Consistent with previous data, resting femoral blood flow and FVC were approximately 30% lower in older compared with young men (P < 0.05). Maximal vasoconstrictor responses to tyramine (-30 +/- 3 versus -41 +/- 3%), phenylephrine (-25 +/- 4 versus -45 +/- 5%), and dexmedetomidine (-22 +/- 4 versus -44 +/- 3%) were all significantly lower in older compared with young men (all P < 0.05). Our results indicate that human ageing is associated with a reduction in leg postjunctional alpha-adrenoceptor responsiveness to endogenous NA release, and this reduction is evident for both alpha1- and alpha2-adrenoceptors. However, given that basal leg vascular conductance is reduced with age and is primarily mediated by sympathetic vasoconstriction, impaired alpha-adrenoceptor responsiveness does not negate the ability of the sympathetic nervous system to evoke greater tonic vasoconstriction in the leg vasculature of older men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.