Evidence map›Paper›PMID 17460111›Full record

ArticleClinical and vaccine immunology : CVI2007

Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.

Ana Cehovin, Jacqueline M Cliff, Philip C Hill, Roger H Brookes, Hazel M Dockrell

Open access · diamondAbstract readComparative Study
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Two-HitFrontiers in immunology · 2019
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Reproducibility of QuantiFERON-TB gold in-tube assay.Clinical and vaccine immunology : CVI · 2008
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ana CehovinDepartment of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom. a.cehovin@ucl.ac.uk
Jacqueline M Cliff
Philip C Hill
Roger H Brookes
Hazel M Dockrell
MRC Unit the Gambia · GMLondon School of Hygiene & Tropical Medicine · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.

Indexed as

Biological AssayVirus LatencyAdolescentAdultAgedAntigens, BacterialFemaleHumansInterferon-gammaMaleMiddle AgedMycobacterium tuberculosisSensitivity and SpecificityTime FactorsTuberculosisAntigens, BacterialInterferon-gamma

Identifiers

PMID17460111
PMCPMC1951098
OpenAlexW2097340616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.